Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy
المؤلفون المشاركون
Newman, Robert H.
Ongeri, Elimelda Moige
Cao, Lei
Boston, Ava
Jegede, Olugbemiga
Harrison, Scott H.
Sedighi, Rashin
Premadasa, Lakmini
Pinder, Jamilla
Crawford, George E.
المصدر
International Journal of Nephrology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-29
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Diabetes is the leading cause of chronic kidney disease.
African Americans are disproportionately burdened by diabetic kidney disease (DKD) and end stage renal disease (ESRD).
Disparities in DKD have genetic and socioeconomic components, yet its prevalence in African Americans is not adequately studied.
The current study used multiple biomarkers of DKD to evaluate undiagnosed DKD in uninsured and underinsured African American men in Greensboro, North Carolina.
Participants consisted of three groups: nondiabetic controls, diabetic patients without known kidney disease, and diabetic patients with diagnosed DKD.
Our data reveal undiagnosed kidney injury in a significant proportion of the diabetic patients, based on levels of both plasma and urinary biomarkers of kidney injury, namely, urinary albumin to creatinine ratio, kidney injury molecule-1, cystatin C, and neutrophil gelatinase-associated lipocalin.
We also found that the urinary levels of meprin A, meprin B, and two kidney meprin targets (nidogen-1 and monocytes chemoattractant protein-1) increased with severity of kidney injury, suggesting a potential role for meprin metalloproteases in the pathophysiology of DKD in this subpopulation.
The study also demonstrates a need for more aggressive tests to assess kidney injury in uninsured diabetic patients to facilitate early diagnosis and targeted interventions that could slow progression to ESRD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Lei& Sedighi, Rashin& Boston, Ava& Premadasa, Lakmini& Pinder, Jamilla& Crawford, George E.…[et al.]. 2018. Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy. International Journal of Nephrology،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1173656
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Lei…[et al.]. Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy. International Journal of Nephrology No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1173656
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Lei& Sedighi, Rashin& Boston, Ava& Premadasa, Lakmini& Pinder, Jamilla& Crawford, George E.…[et al.]. Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy. International Journal of Nephrology. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1173656
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173656
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر