Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells
المؤلفون المشاركون
Crous, Anine
Chizenga, Elvin
Hodgkinson, Natasha
Abrahamse, H.
المصدر
International Journal of Optics
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Cancer is a global burden that has prompted extensive research into prevention and treatment, over many decades.
Scientific studies have shown that subset of cells within a tumour, known as cancer stem cells (CSCs), are responsible for tumourigenesis, metastasis, drug resistance, and recurrences.
CSCs have characteristic features of enhanced self-renewal, proliferation, and limited but multidirectional differentiation capacity.
The discovery of CSCs has initiated extensive research into novel cancer treatment regimes.
Evidence indicates that CSCs are resistant to conventional chemo- and radiation therapy leading to treatment failures, cancer metastasis, secondary cancer formation, and relapse.
Because of the observed phenomena in the course of cancer prognosis, a need for treatment modalities targeting CSCs is important.
Photodynamic therapy (PDT) is a clinically approved, minimally invasive, therapeutic procedure that can exert a selective cytotoxic activity toward cancerous cells while reducing toxicity to normal cells.
It uses a photosensitizer (PS) that becomes excited when subjected to light at a specific wavelength, and the PS forms reactive oxygen species (ROS) killing malignant cells.
Currently, PDT is being investigated as a target specific treatment for CSCs by the addition of carrier molecules and antibody conjugates bound to the PS.
Targeted PDT (TPDT) may be able to not only eradicate the tumour mass but kill CSCs as well.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Crous, Anine& Chizenga, Elvin& Hodgkinson, Natasha& Abrahamse, H.. 2018. Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells. International Journal of Optics،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1173748
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Crous, Anine…[et al.]. Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells. International Journal of Optics No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1173748
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Crous, Anine& Chizenga, Elvin& Hodgkinson, Natasha& Abrahamse, H.. Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells. International Journal of Optics. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1173748
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173748
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر