Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion
المؤلفون المشاركون
Cataldo, L. R.
Mizgier, M. L.
Galgani, J. E.
Santos, J. L.
Gutierrez, Juan
Casas, Mariana
Llanos, Paola
Contreras-Ferrat, Ariel E.
Moro, Cedric
Bouzakri, Karim
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Fasting to postprandial transition requires a tight adjustment of insulin secretion to its demand, so tissue (e.g., skeletal muscle) glucose supply is assured while hypo-/hyperglycemia are prevented.
High muscle glucose disposal after meals is pivotal for adapting to increased glycemia and might drive insulin secretion through muscle-released factors (e.g., myokines).
We hypothesized that insulin influences myokine secretion and then increases glucose-stimulated insulin secretion (GSIS).
In conditioned media from human myotubes incubated with/without insulin (100 nmol/L) for 24 h, myokines were qualitatively and quantitatively characterized using an antibody-based array and ELISA-based technology, respectively.
C57BL6/J mice islets and Wistar rat beta cells were incubated for 24 h with control and conditioned media from noninsulin- and insulin-treated myotubes prior to GSIS determination.
Conditioned media from insulin-treated versus nontreated myotubes had higher RANTES but lower IL6, IL8, and MCP1 concentration.
Qualitative analyses revealed that conditioned media from noninsulin- and insulin-treated myotubes expressed 32 and 23 out of 80 myokines, respectively.
Islets incubated with conditioned media from noninsulin-treated myotubes had higher GSIS versus control islets (p<0.05).
Meanwhile, conditioned media from insulin-treated myotubes did not influence GSIS.
In beta cells, GSIS was similar across conditions.
In conclusion, factors being present in noninsulin-stimulated muscle cell-derived media appear to influence GSIS in mice islets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mizgier, M. L.& Cataldo, L. R.& Gutierrez, Juan& Santos, J. L.& Casas, Mariana& Llanos, Paola…[et al.]. 2017. Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1173749
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mizgier, M. L.…[et al.]. Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1173749
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mizgier, M. L.& Cataldo, L. R.& Gutierrez, Juan& Santos, J. L.& Casas, Mariana& Llanos, Paola…[et al.]. Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1173749
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173749
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر