Silymarin Ameliorates Diabetes-Induced Proangiogenic Response in Brain Endothelial Cells through a GSK-3β Inhibition-Induced Reduction of VEGF Release
المؤلفون المشاركون
Alhusban, Ahmed
Alkhazaleh, Enaam
El-Elimat, Tamam
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Diabetes mellitus (DM) is a major risk factor for cardiovascular disease.
Additionally, it was found to induce a dysfunctional angiogenic response in the brain that was attributed to oxidative stress.
Milk thistle seed extract (silymarin) has potent antioxidant properties, though its potential use in ameliorating diabetes-induced aberrant brain angiogenesis is unknown.
Glycogen synthase kinase-3β is a regulator of angiogenesis that is upregulated by diabetes.
Its involvement in diabetes-induced angiogenesis is unknown.
To evaluate the potential of silymarin to ameliorate diabetes-induced aberrant angiogenesis, human brain endothelial cells (HBEC-5i) were treated with 50 μg/mL advanced glycation end (AGE) products in the presence or absence of silymarin (50, 100 μM).
The angiogenic potential of HBEC-5i was evaluated in terms of migration and in vitro tube formation capacities.
The involvement of GSK-3β was also evaluated.
AGE significantly increased the migration and tube formation rates of HBEC-5i by about onefold (p=0.0001).
Silymarin reduced AGE-induced migration in a dose-dependent manner where 50 μM reduced migration by about 50%, whereas the 100 μM completely inhibited AGE-induced migration.
Similarly, silymarin 50 μg/mL blunted AGE-induced tube formation (p=0.001).
This effect was mediated through a GSK-3β-dependent inhibition of VEGF release.
In conclusion, silymarin inhibits AGE-induced aberrant angiogenesis in a GSK-3β-mediated inhibition of VEGF release.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alhusban, Ahmed& Alkhazaleh, Enaam& El-Elimat, Tamam. 2017. Silymarin Ameliorates Diabetes-Induced Proangiogenic Response in Brain Endothelial Cells through a GSK-3β Inhibition-Induced Reduction of VEGF Release. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1173910
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alhusban, Ahmed…[et al.]. Silymarin Ameliorates Diabetes-Induced Proangiogenic Response in Brain Endothelial Cells through a GSK-3β Inhibition-Induced Reduction of VEGF Release. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1173910
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alhusban, Ahmed& Alkhazaleh, Enaam& El-Elimat, Tamam. Silymarin Ameliorates Diabetes-Induced Proangiogenic Response in Brain Endothelial Cells through a GSK-3β Inhibition-Induced Reduction of VEGF Release. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1173910
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173910
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر