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Clinical Outcomes of Myocarditis after Moderate-Dose Steroid Therapy in Systemic Sclerosis: A Pilot Study
المؤلفون المشاركون
Pussadhamma, Burabha
Tipparot, Thapanee
Chaosuwannakit, Naruemol
Mahakkanukrauh, Ajanee
Suwannaroj, Siraphop
Nanagara, Ratanavadee
Foocharoen, Chingching
المصدر
International Journal of Rheumatology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Myocarditis is reported in systemic sclerosis (SSc); however, treatment options and outcomes are limited.
Our objective was to define cardiac outcomes after moderate-dose steroid therapy in SSc patients with myocarditis.
Method.
An open-label study was conducted among SSc patients with myocarditis—as defined by cardiovascular magnetic resonance (CMR), disease onset <5 years, and a NYHA functional class ≥II.
All enrolled patients received prednisolone (30 mg/d) which would be tapered off by week 24, and CMR was followed up at the end of treatment.
Results.
A total of 20 SSc patients were enrolled which 12 patients completed the study.
At week 24, 8 of the 12 cases experienced improvement of myocarditis.
Compared to those with no improvement, these 8 patients had significantly longer disease duration (p=0.03), higher heart rate at baseline (p=0.049) and week 24 (p=0.04), lower left ventricular (LV) and right ventricular (RV) stroke volume at baseline (p=0.002 and p=0.01) and week 24 (p=0.01 and p=0.02), and lower LV and RV cardiac output at week 24 (p=0.01 and p=0.01).
Four cases died during follow-up (3 due to cardiac complications, 1 due to renal crisis).
The two who died from heart failure had very high NT-prohormone-brain natriuretic peptide (NT-proBNP) and impaired LV ejection fraction (LVEF), and the one who died from arrhythmia had very high sensitivity of cardiac Troponin-T (hs-cTnT).
Conclusions.
Moderate-dose steroid therapy may improve myocarditis in SSc.
A proportion of patients died due to cardiac complications during treatment, particularly those with high hs-cTnT, high NT-proBNP, and impaired LVEF.
This trial is registered with NCT03607071.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pussadhamma, Burabha& Tipparot, Thapanee& Chaosuwannakit, Naruemol& Mahakkanukrauh, Ajanee& Suwannaroj, Siraphop& Nanagara, Ratanavadee…[et al.]. 2020. Clinical Outcomes of Myocarditis after Moderate-Dose Steroid Therapy in Systemic Sclerosis: A Pilot Study. International Journal of Rheumatology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1173990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pussadhamma, Burabha…[et al.]. Clinical Outcomes of Myocarditis after Moderate-Dose Steroid Therapy in Systemic Sclerosis: A Pilot Study. International Journal of Rheumatology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1173990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pussadhamma, Burabha& Tipparot, Thapanee& Chaosuwannakit, Naruemol& Mahakkanukrauh, Ajanee& Suwannaroj, Siraphop& Nanagara, Ratanavadee…[et al.]. Clinical Outcomes of Myocarditis after Moderate-Dose Steroid Therapy in Systemic Sclerosis: A Pilot Study. International Journal of Rheumatology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1173990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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