Diabetic Retinopathy in the Spontaneously Diabetic Torii Rat: Pathogenetic Mechanisms and Preventive Efficacy of Inhibiting the Urokinase-Type Plasminogen Activator Receptor System
المؤلفون المشاركون
Dal Monte, Massimo
Rusciano, Dario
Cammalleri, Maurizio
Locri, Filippo
Marsili, Stefania
Lista, Liliana
De Rosa, Mario
Pavone, Vincenzo
Bagnoli, Paola
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
The spontaneously diabetic Torii (SDT) rat is of increasing preclinical interest because of its similarities to human type 2 diabetic retinopathy (DR).
The system formed by urokinase-type plasminogen activator (uPA) and its receptor (uPAR) is a player in blood-retinal barrier (BRB) breakdown in DR.
Here, we investigated whether in SDT rats, preventive administration of UPARANT, an inhibitor of the uPAR pathway, counteracts the retinal impairment in response to chronic hyperglycemia.
Electroretinogram (ERG) monitoring was followed over time.
Fluorescein-dextran microscopy, CD31 immunohistochemistry, quantitative PCR, ELISA, Evans blue perfusion, and Western blot were also used.
UPARANT prevented ERG dysfunction, upregulation of vascular endothelial growth factor and fibroblast growth factor-2, BRB leakage, gliosis, and retinal cell death.
The mechanisms underlying UPARANT benefits were studied comparing them with the acute streptozotocin (STZ) model in which UPARANT is known to inhibit DR signs.
In SDT rats, but not in the STZ model, UPARANT downregulated the expression of uPAR and its membrane partners.
In both models, UPARANT reduced the levels of transcription factors coupled to inflammation or inflammatory factors themselves.
These findings may help to establish the uPAR system as putative target for the development of novel drugs that may prevent type 2 DR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cammalleri, Maurizio& Dal Monte, Massimo& Locri, Filippo& Marsili, Stefania& Lista, Liliana& De Rosa, Mario…[et al.]. 2017. Diabetic Retinopathy in the Spontaneously Diabetic Torii Rat: Pathogenetic Mechanisms and Preventive Efficacy of Inhibiting the Urokinase-Type Plasminogen Activator Receptor System. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1174029
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cammalleri, Maurizio…[et al.]. Diabetic Retinopathy in the Spontaneously Diabetic Torii Rat: Pathogenetic Mechanisms and Preventive Efficacy of Inhibiting the Urokinase-Type Plasminogen Activator Receptor System. Journal of Diabetes Research No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1174029
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cammalleri, Maurizio& Dal Monte, Massimo& Locri, Filippo& Marsili, Stefania& Lista, Liliana& De Rosa, Mario…[et al.]. Diabetic Retinopathy in the Spontaneously Diabetic Torii Rat: Pathogenetic Mechanisms and Preventive Efficacy of Inhibiting the Urokinase-Type Plasminogen Activator Receptor System. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1174029
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174029
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر