Enabling Microparticle Imprinting to Achieve Penetration and Local Endurance in the Peritoneum via High-Intensity Ultrasound (HIUS) for the Treatment of Peritoneal Metastasis
المؤلفون المشاركون
Zacharski, Maciej
Khosrawipour, Veria
Martino, Alice
Khosrawipour, Tanja
Mikolajczyk, Agata
Kulas, Joanna
Pieczka, Marek
Nicpon, Jakub
المصدر
International Journal of Surgical Oncology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Micro- and nanoparticles, with their submicron size, the versatility of physical and chemical properties, and easily modifiable surface, are uniquely positioned to bypass the body’s clearing systems.
Nonetheless, two main problems with micro- and nanoparticles arise which limit the intraperitoneal application.
The study was performed to evaluate whether HIUS enables the imprinting of microparticles and, therefore, enhances penetration and local endurance in the peritoneum.
Methods.
High-intensity ultrasound (HIUS) at 20 kilohertz with an output power of 70 W was applied on peritoneal tissue samples from fresh postmortem swine for different time intervals.
Before the HIUS application, the surface of the samples was covered with strontium aluminate microparticles before analysis via electron microscopy.
In-tissue strontium aluminate penetration and particle distribution size were measured using fluorescence microscopy on frozen thin sections.
Results.
With increasing HIUS durations (1 versus 5 minutes), increasing strontium aluminate particles were detected in the peritoneum.
HIUS leads to a particle selection process with enhancing predominantly the penetration of smaller particles whereas larger particles had a harder time penetrating the peritoneum.
Smaller particles were detected up to 277 µm ± 86 µm into the peritoneum.
Conclusion.
Our data indicate that HIUS might be used as a method to prepare the peritoneal tissue for micro- and nanoparticles.
Higher tissue penetration rates without the increase and longer local endurance of the applied substance could be reached.
More studies need to be performed to analyze the effect of HIUS in enhancing intraperitoneal drug applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mikolajczyk, Agata& Khosrawipour, Tanja& Martino, Alice& Kulas, Joanna& Pieczka, Marek& Zacharski, Maciej…[et al.]. 2020. Enabling Microparticle Imprinting to Achieve Penetration and Local Endurance in the Peritoneum via High-Intensity Ultrasound (HIUS) for the Treatment of Peritoneal Metastasis. International Journal of Surgical Oncology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1174179
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mikolajczyk, Agata…[et al.]. Enabling Microparticle Imprinting to Achieve Penetration and Local Endurance in the Peritoneum via High-Intensity Ultrasound (HIUS) for the Treatment of Peritoneal Metastasis. International Journal of Surgical Oncology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1174179
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mikolajczyk, Agata& Khosrawipour, Tanja& Martino, Alice& Kulas, Joanna& Pieczka, Marek& Zacharski, Maciej…[et al.]. Enabling Microparticle Imprinting to Achieve Penetration and Local Endurance in the Peritoneum via High-Intensity Ultrasound (HIUS) for the Treatment of Peritoneal Metastasis. International Journal of Surgical Oncology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1174179
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174179
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر