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Serum Endothelin-1 Correlates with Myocardial Injury and Independently Predicts Adverse Cardiac Events in Non-ST-Elevation Acute Myocardial Infarction
المؤلفون المشاركون
Setianto, Budi Yuli
Sukmasari, Indah
Puspitawati, Ira
Hartopo, Anggoro Budi
المصدر
International Journal of Vascular Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Serum endothelin-1 is increasingly released in acute myocardial infarction, by necrotic cardiomyocytes.
In non-ST-elevation acute myocardial infarction (Non-STEMI), increased serum endothelin-1 on-admission may have clinical significance during acute hospitalisation events.
Objective.
The purpose of this study is to investigate whether increased serum endothelin-1 level predict adverse cardiac events in patients hospitalized with Non-STEMI.
Methods.
The design of this research was a prospective cohort study.
Consecutive subjects with Non-STEMI undergoing symptom onset ≤24 hour were enrolled and observed during intensive hospitalization.
Serum endothelin-1, troponin-I, and hs-C reactive protein were measured from peripheral blood taken on-admission.
In-hospital adverse cardiac events were a composite of death, acute heart failure, cardiogenic shock, reinfarction, and resuscitated VT/VF.
Results.
We enrolled 66 subjects.
The incidence of in-hospital adverse cardiac events is 13.6% (10 out of 66 subjects).
Serum endothelin-1 level was significantly higher in subjects with in-hospital adverse cardiac events.
Subjects with endothelin-1 level >2.59 pg/mL independently predicted adverse cardiac events in hospitalised Non-STEMI patients (adjusted odds ratio 44.43, 95% confidence interval: 1.44-1372.99, p value 0.03).
The serum endothelin-1 level was correlated with serum troponin I level (correlation coefficient of 0.413, p value 0.012).
Conclusion.
Increased serum endothelin-1 on-admission correlated with increased troponin-I and independently predicted in-hospital adverse cardiac events in patients with Non-STEMI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hartopo, Anggoro Budi& Sukmasari, Indah& Puspitawati, Ira& Setianto, Budi Yuli. 2020. Serum Endothelin-1 Correlates with Myocardial Injury and Independently Predicts Adverse Cardiac Events in Non-ST-Elevation Acute Myocardial Infarction. International Journal of Vascular Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1174239
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hartopo, Anggoro Budi…[et al.]. Serum Endothelin-1 Correlates with Myocardial Injury and Independently Predicts Adverse Cardiac Events in Non-ST-Elevation Acute Myocardial Infarction. International Journal of Vascular Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1174239
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hartopo, Anggoro Budi& Sukmasari, Indah& Puspitawati, Ira& Setianto, Budi Yuli. Serum Endothelin-1 Correlates with Myocardial Injury and Independently Predicts Adverse Cardiac Events in Non-ST-Elevation Acute Myocardial Infarction. International Journal of Vascular Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1174239
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174239
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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