Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy
المؤلفون المشاركون
Carmosino, Monica
Gesualdo, Loreto
Rossi, Luigi
Nicoletti, Maria Celeste
Mastrofrancesco, Lisa
Di Franco, Antonella
Indrio, Francesca
Lella, Rossella
Laviola, Luigi
Svelto, Maria
Procino, Giuseppe
Giorgino, F.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Diabetic nephropathy (DN) is a microangiopathic complication of diabetes mellitus (DM) affecting one-third of diabetic patients.
The large variability in the clinical presentation of renal involvement in patients with DM makes kidney biopsy a prerequisite for a correct diagnosis.
However, renal biopsy is an invasive procedure associated with risk of major complications.
Numerous studies aimed to identify a noninvasive biomarker of DN but, so far, none of these is considered to be sufficiently specific and sensitive.
Water channel aquaporins (AQPs), expressed at the plasma membrane of epithelial tubular cells, are often dysregulated during DN.
In this work, we analyzed the urine excretion of AQP5 and AQP2 (uAQP5 and uAQP2), via exosomes, in 35 diabetic patients: 12 normoalbuminuric with normal renal function (DM), 11 with proteinuric nondiabetic nephropathy (NDN), and 12 with histological diagnosis and classification of DN.
ELISA and WB analysis independently showed that uAQP5 was significantly increased in DN patients.
Interestingly, linear regression analysis showed a positive correlation between uAQP5 and the histological class of DN.
The same analysis, focusing on uAQP2, showed comparable results.
Taken together, these data suggest a possible use of AQP5 and AQP2 as novel noninvasive biomarkers to help in classifying the clinical stage of DN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rossi, Luigi& Nicoletti, Maria Celeste& Carmosino, Monica& Mastrofrancesco, Lisa& Di Franco, Antonella& Indrio, Francesca…[et al.]. 2017. Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1174289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rossi, Luigi…[et al.]. Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. Journal of Diabetes Research No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1174289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rossi, Luigi& Nicoletti, Maria Celeste& Carmosino, Monica& Mastrofrancesco, Lisa& Di Franco, Antonella& Indrio, Francesca…[et al.]. Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1174289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر