![](/images/graphics-bg.png)
Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women
المؤلفون المشاركون
Nicolucci, Antonio
Stuppia, Liborio
Franzago, Marica
Fraticelli, Federica
Celentano, Claudio
Liberati, Marco
Vitacolonna, Ester
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Gestational diabetes mellitus (GDM) is the most frequent metabolic disorder in pregnancy.
Women with a GDM history are at increased risk of developing diabetes and cardiovascular diseases.
Studies have demonstrated a significant correlation between several genes involved in the metabolic pathway of insulin and environmental factors.
The aim of this study was to investigate the relationship between clinical parameters in GDM and variants in genes involved with nutrients and metabolism.
Several variants PPARG2 rs1801282 (C>G); PPARGC1A rs8192678 (C>T); TCF7L2 rs7903146 (C>T); LDLR rs2228671 (C>T); MTHFR rs1801133 (C>T); APOA5 rs662799 (T>C); GCKR rs1260326 (C>T); FTO rs9939609 (T>A); MC4R rs17782313 (T>C) were genotyped in 168 pregnant Caucasian women with or without GDM by High Resolution Melting (HRM) analysis.
A significant correlation was observed between TT genotype of TCF7L2 gene and increased risk of GDM (OR 5.4 [95% CI 1.5–19.3]).
Moreover, a significant correlation was observed between lipid parameters and genetic variations in additional genes, namely, PPARG2 [p = 0,02], APOA5 [p = 0,02], MC4R [p = 0,03], LDLR [p = 0,01], and FTO [p = 0,02].
Our findings support the association between TCF7L2 rs7903146 variant and an increased GDM risk.
Results about the investigated genetic variants provide important information about cardiometabolic risk in GDM and help to plan future prevention studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Franzago, Marica& Fraticelli, Federica& Nicolucci, Antonio& Celentano, Claudio& Liberati, Marco& Stuppia, Liborio…[et al.]. 2017. Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1174310
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Franzago, Marica…[et al.]. Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women. Journal of Diabetes Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1174310
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Franzago, Marica& Fraticelli, Federica& Nicolucci, Antonio& Celentano, Claudio& Liberati, Marco& Stuppia, Liborio…[et al.]. Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1174310
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174310
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)