Extended-Spectrum β-Lactamase (ESBL) Genotypes among Multidrug-Resistant Uropathogenic Escherichia coli Clinical Isolates from a Teaching Hospital of Nepal
المؤلفون المشاركون
Parajuli, Narayan Prasad
Joshi, Govardhan
Rijal, Basista
Pandit, Roshan
Shrestha, Sumesh Shreekhanda
Awal, Balkrishna
المصدر
Interdisciplinary Perspectives on Infectious Diseases
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Urinary tract infections (UTI) represent the most common bacterial infections among patients visiting outpatient clinics of healthcare centers in Nepal.
However, treatment of such infections is compounded by emergence and spread of multidrug-resistant uropathogens associated with extended-spectrum β-lactamases (ESBLs).
In this study, we aimed to investigate the burden of antimicrobial resistance and occurrence of ESBL genes among clinical isolates of uropathogenic Escherichia coli at a tertiary care teaching hospital of Nepal.
During the study period, we processed a total of 1,626 urinary tract specimens, isolated significant bacterial pathogens, and investigated their antimicrobial susceptibilities.
Escherichia coli (n = 154), the predominant pathogen associated with UTI, was further investigated for the existence of ESBL enzymes by using conventional phenotypic as well as molecular approaches.
Among suspected cases of UTI, we found that 15.2% were having UTI and female patients of the reproductive age group were more affected (p<0.05).
Escherichia coli (154, 62.1%) was the key uropathogen, and majority (∼64.9%) of them were multidrug resistant (MDR).
Among MDR E.
coli isolates, 40.3% were producing extended-spectrum β-lactamases (ESBLs).
bla-TEM (83.8%), bla-CTX-M (66.1%), and bla-SHV (4.8%) were common ESBL genotypes.
Nitrofurantoin, gentamycin, and imipenem were the most effective antibiotics for ESBL-producing Escherichia coli isolates.
It indicates that the high rates of multidrug-resistant Escherichia coli are frequent causes of UTI in our hospital.
Nitrofurantoin and aminoglycosides are the most useful first-line drugs to be used in the cases of UTI.
We recommend the regular investigation of drug resistance among all isolates and develop a useful antibiotic prescription policy in our country.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pandit, Roshan& Awal, Balkrishna& Shrestha, Sumesh Shreekhanda& Joshi, Govardhan& Rijal, Basista& Parajuli, Narayan Prasad. 2020. Extended-Spectrum β-Lactamase (ESBL) Genotypes among Multidrug-Resistant Uropathogenic Escherichia coli Clinical Isolates from a Teaching Hospital of Nepal. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174346
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pandit, Roshan…[et al.]. Extended-Spectrum β-Lactamase (ESBL) Genotypes among Multidrug-Resistant Uropathogenic Escherichia coli Clinical Isolates from a Teaching Hospital of Nepal. Interdisciplinary Perspectives on Infectious Diseases No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1174346
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pandit, Roshan& Awal, Balkrishna& Shrestha, Sumesh Shreekhanda& Joshi, Govardhan& Rijal, Basista& Parajuli, Narayan Prasad. Extended-Spectrum β-Lactamase (ESBL) Genotypes among Multidrug-Resistant Uropathogenic Escherichia coli Clinical Isolates from a Teaching Hospital of Nepal. Interdisciplinary Perspectives on Infectious Diseases. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174346
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174346
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر