High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report
المؤلفون المشاركون
Izawa, Shoichiro
Okura, Tsuyoshi
Ueta, Etsuko
Nakamura, Risa
Fujioka, Yohei
Sumi, Keisuke
Matsumoto, Kazuhisa
Shoji, Kyoko
Matsuzawa, Kazuhiko
Nomi, Yuri
Mihara, Hitomi
Otsuka, Yuzuru
Kato, Masahiko
Taniguchi, Shin-ichi
Yamamoto, Kazuhiro
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM).
They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects.
We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum.
Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM.
Methods.
Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants.
We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1).
Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp.
Results.
CML and CEL levels were significantly higher in T2DM than non-DM participants.
CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants.
There was no correlation between any of the AGEs measured and glucose disposal rate.
Conclusions.
These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Okura, Tsuyoshi& Ueta, Etsuko& Nakamura, Risa& Fujioka, Yohei& Sumi, Keisuke& Matsumoto, Kazuhisa…[et al.]. 2017. High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1174403
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Okura, Tsuyoshi…[et al.]. High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report. Journal of Diabetes Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1174403
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Okura, Tsuyoshi& Ueta, Etsuko& Nakamura, Risa& Fujioka, Yohei& Sumi, Keisuke& Matsumoto, Kazuhisa…[et al.]. High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1174403
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174403
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر