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Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes Mellitus
المؤلفون المشاركون
Shimoda, Masashi
Miyoshi-Takai, Maiko
Irie, Shintaro
Tanabe, Akihito
Obata, Atsushi
Okauchi, Seizo
Hirukawa, Hidenori
Kimura, Tomohiko
Kohara, Kenji
Kamei, Shinji
Mune, Tomoatsu
Kaku, Kohei
Kaneto, Hideaki
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Dipeptidyl peptidase-4 (DPP-4) inhibitors are often used all over the world and exert various beneficial effects including glucose-lowering effect in many subjects with type 2 diabetes.
It is poorly understood, however, which factors are closely related with the durability of glucose-lowering effect by DPP-4 inhibitor.
In this study, we examined retrospectively which factors could mainly influence the durability of DPP-4 inhibitor.
We enrolled 212 participants with type 2 diabetes to whom DPP-4 inhibitor was administered for over 1 year without an addition or increase of other hypoglycemic agents.
Age and baseline HbA1c level were significantly higher in the effective group than those in the ineffective group.
The effective group had a tendency of smaller amounts of weight change, average total cholesterol, and average triglyceride compared with the ineffective group.
Multiple logistic regression analysis showed that average triglyceride and baseline HbA1c were independent predictors associated with the durability of DPP-4 inhibitor.
Moreover, an average triglyceride level contributed to the durability of DPP-4 inhibitor in the obese group (BMI ≥ 25 kg/m2) but not in the nonobese group (BMI < 25 kg/m2).
These results suggest the importance of strict triglyceride management to maintain the durability of glucose-lowering effect by DPP-4 inhibitor, especially in obese subjects with type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shimoda, Masashi& Miyoshi-Takai, Maiko& Irie, Shintaro& Tanabe, Akihito& Obata, Atsushi& Okauchi, Seizo…[et al.]. 2017. Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174509
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shimoda, Masashi…[et al.]. Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1174509
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shimoda, Masashi& Miyoshi-Takai, Maiko& Irie, Shintaro& Tanabe, Akihito& Obata, Atsushi& Okauchi, Seizo…[et al.]. Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174509
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174509
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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