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Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency
المؤلفون المشاركون
Alkan, Gülsüm
Keles, Sevgi
Reisli, İsmail
المصدر
International Journal of Pediatrics
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder (PID) that typically presents with hypogammaglobulinemia and impaired antibody production.
Objectives.
This study aimed to promote the awareness of CVID, whose clinical spectrum is quite broad.
Methods.
The demographic, clinical, and laboratory characteristics of 12 children (seven males and five females) with CVID were analyzed retrospectively.
The patients were diagnosed using the diagnostic criteria of the European Society for Primary Immunodeficiencies.
Results.
The median disease onset age was 7.2±4.1 years, and the mean diagnosis age was 11.6±3.7 years.
The diagnosis delay was 4.3±2.6 years, and the parental consanguinity rate was 75%.
Most patients presented with recurrent infections, including upper respiratory tract infections (n=8), lower respiratory tract infections (n=9), and gastroenteritis (n=5).
In addition, growth retardation (n=9) and bronchiectasis (n=5) were common comorbidities.
Two patients presented with autoimmune thrombocytopenia and anemia, and one patient exhibited lung empyema.
All the patients had immunoglobulin G deficiencies.
Conclusion.
CVID is a heterogeneous disease, so the diagnosis is frequently delayed.
In the CVID patients with pulmonary complications, relationships were seen with the diagnosis delay, symptom onset age, and lung infection prevalence.
Overall, the early diagnosis and treatment of PIDs can preclude life-threatening complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alkan, Gülsüm& Keles, Sevgi& Reisli, İsmail. 2018. Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency. International Journal of Pediatrics،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1174629
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alkan, Gülsüm…[et al.]. Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency. International Journal of Pediatrics No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1174629
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alkan, Gülsüm& Keles, Sevgi& Reisli, İsmail. Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency. International Journal of Pediatrics. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1174629
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174629
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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