Diagnostic and Prognostic Validity of Proadrenomedullin among Neonates with Sepsis in Tertiary Care Hospitals of Southern India
المؤلفون المشاركون
Mithra, Prasanna
Rao, Suchetha
Bhat, Kamalakshi G.
Dhanashree, Biranthabail
Kannan, Raja
Baliga, Shantharam
المصدر
International Journal of Pediatrics
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-01
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
To evaluate Proadrenomedullin (Pro-ADM) as the diagnostic and prognostic marker in neonatal sepsis.
Materials and Methods.
In this cross-sectional study, Pro-ADM levels were estimated in 54 neonates with clinical sepsis and positive sepsis screen (cases) and 54 controls without clinical sepsis.
Repeat Pro-ADM levels were estimated after 72 hours in cases.
Pro-ADM levels were compared with the clinical outcome.
Results and Discussion.
Median Pro-ADM levels in cases were 31.8 (IQR: 27.8-39.4) pmol/ml which was significantly higher than controls 5.1 (IQR; 3.1-7.7) pmol/ml.
From the constructed ROC curve, a value of 14.5 pmol/ml was taken as the cut-off for sepsis.
Pro-ADM had 100% sensitivity, specificity, and positive predictive values (PPV) in detecting sepsis at 14.5 pmol/ml.
Among cases, a decrease in Pro-ADM level by 10 pmol/ml was associated with 99% survival.
Pro-ADM value of 35 pmol/ml had 100% specificity and PPV in predicting mortality.
Conclusion.
Pro-ADM can be used as a single biomarker for detecting neonatal sepsis, predicting clinical outcome and prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kannan, Raja& Rao, Suchetha& Mithra, Prasanna& Dhanashree, Biranthabail& Baliga, Shantharam& Bhat, Kamalakshi G.. 2018. Diagnostic and Prognostic Validity of Proadrenomedullin among Neonates with Sepsis in Tertiary Care Hospitals of Southern India. International Journal of Pediatrics،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1174688
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kannan, Raja…[et al.]. Diagnostic and Prognostic Validity of Proadrenomedullin among Neonates with Sepsis in Tertiary Care Hospitals of Southern India. International Journal of Pediatrics No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1174688
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kannan, Raja& Rao, Suchetha& Mithra, Prasanna& Dhanashree, Biranthabail& Baliga, Shantharam& Bhat, Kamalakshi G.. Diagnostic and Prognostic Validity of Proadrenomedullin among Neonates with Sepsis in Tertiary Care Hospitals of Southern India. International Journal of Pediatrics. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1174688
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174688
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر