Simultaneous Determination of Six Chromones in Saposhnikoviae Radix via Quantitative Analysis of Multicomponents by Single Marker
المؤلفون المشاركون
Jiang, YanYan
Wang, Lu
Zhang, Jinhua
Chen, Luxiao
Qiu, Junna
Zhang, Yu
Jiang, Lijuan
Liu, Bin
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-14
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
A method, quantitative analysis of multicomponents by single marker (QAMS), was established and fully verified based on high-performance liquid chromatography (HPLC) for simultaneous determination of six chromone indicators of Saposhnikoviae Radix (SR).
In the present study, cimifugin (C), 5-O-methylvisamminol (V), hamaudol (H), and their corresponding glycosides, prim-O-glucosylcimifugin (GC), 4′-O-β-D-glucosyl-5-O-methylvisamminol (GV), and sec-O-glucosylhamaudol (GH), were selected as bioactive constituents and indicators for the quality evaluation of SR.
GV was chosen as the unique reference standard, and relative correction factors (RCF) between GV and the other five chromones were calculated.
The feasibility of QAMS for the analysis of chromones was investigated by comparing with the traditional external standard method (ESM).
Furthermore, the method was proven to have accuracy (96.98%–102.50%), repeatability (RSD <3%), stability (RSD <3%), precision (RSD <3%), and desirable linearity (R2 ≧0.9999).
Subsequently, 55 batches of commercial SR from different regions were determined by QAMS, and their contents were analyzed by principal component analysis (PCA), correlation analysis, and hierarchical cluster analysis (HCA), respectively.
Based on the results, a more refined quality standard of commercial SR was proposed: SR was qualified when the total contents of six chromones were greater than 3 mg·g−1.
Furthermore, SR could initially be regarded as a superior medicine when it satisfied both conditions at the same time: the total content of GC, C, GV, V, GH, and H was greater than 8 mg·g−1, and the proportion of the total content of C, V, and H was greater than 10%.
This study demonstrated that the quality of SR could be successfully evaluated by the developed QAMS method; meanwhile, valuable information was provided for improving the quality standard of SR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Jinhua& Chen, Luxiao& Qiu, Junna& Zhang, Yu& Wang, Lu& Jiang, Lijuan…[et al.]. 2020. Simultaneous Determination of Six Chromones in Saposhnikoviae Radix via Quantitative Analysis of Multicomponents by Single Marker. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1174853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Jinhua…[et al.]. Simultaneous Determination of Six Chromones in Saposhnikoviae Radix via Quantitative Analysis of Multicomponents by Single Marker. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1174853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Jinhua& Chen, Luxiao& Qiu, Junna& Zhang, Yu& Wang, Lu& Jiang, Lijuan…[et al.]. Simultaneous Determination of Six Chromones in Saposhnikoviae Radix via Quantitative Analysis of Multicomponents by Single Marker. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1174853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر