dbdb Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL6J Mice Fed a Western Diet

المؤلفون المشاركون

Burke, Susan J.
Batdorf, Heidi M.
Burk, David H.
Noland, Robert C.
Eder, Adrianna E.
Boulos, Matthew S.
Karlstad, Michael D.
Jason Collier, J.

المصدر

Journal of Diabetes Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-09-06

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to weight-matched genetically obese leptin receptor-deficient mice (db/db).

All mice were monitored for changes in body composition, glycemia, and total body mass.

To objectively compare diet-induced and genetic models of obesity, tissue analyses were conducted using mice with similar body mass.

We found that adipose tissue inflammation was present in both models of obesity.

In addition, distinct alterations in metabolic flexibility were evident between WD-fed mice and db/db mice.

Circulating insulin levels are elevated in each model of obesity, while glucagon was increased only in the db/db mice.

Although both WD-fed and db/db mice exhibited adaptive increases in islet size, the db/db mice also displayed augmented islet expression of the dedifferentiation marker Aldh1a3 and reduced nuclear presence of the transcription factor Nkx6.1.

Based on the collective results put forth herein, we conclude that db/db mice capture key features of human T2D that do not occur in WD-fed C57BL/6J mice of comparable body mass.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Burke, Susan J.& Batdorf, Heidi M.& Burk, David H.& Noland, Robert C.& Eder, Adrianna E.& Boulos, Matthew S.…[et al.]. 2017. dbdb Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL6J Mice Fed a Western Diet. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1174911

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Burke, Susan J.…[et al.]. dbdb Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL6J Mice Fed a Western Diet. Journal of Diabetes Research No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1174911

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Burke, Susan J.& Batdorf, Heidi M.& Burk, David H.& Noland, Robert C.& Eder, Adrianna E.& Boulos, Matthew S.…[et al.]. dbdb Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL6J Mice Fed a Western Diet. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1174911

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1174911