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Establishment of a UPLC-MSMS Method for Studying the Effect of Salt-Processing on Tissue Distribution of Twelve Major Bioactive Components of Qing’e Pills in Rats
المؤلفون المشاركون
Chen, Zhipeng
Lin, Shangyang
Wu, Yu
Hou, Jingxia
Lu, Jinlan
Li, Weidong
Wu, Li
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-17
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Qing’e pills is clinically used for treating osteoporosis in postmenopausal women in China.
Eucommiae Cortex and Psoraleae Fructus are the main herbs of Qing’e pills and are both required to be salt-processed.
In order to study the influence of salt-processing on the tissue distribution of Qing’e pills, a UPLC-MS/MS method was established for studying the tissue distribution of 12 main bioactive ingredients of Qing’e pills in rats.
The linear relationships of the 12 compounds in each tissue were good.
The method was fully validated for its selectivity, accuracy, precision, stability, matrix effect, and extraction recovery.
Then, the validated method was successfully applied for simultaneous determination of the 12 chemical components in Qing’e pills in tissues for the first time.
Areas under the curve (AUC) results showed that, except for pinoresinol diglucoside, psoralen, and isopsoralen, the distribution of the other components was increased in the kidney, uterus, ovary, and testes.
Relative targeting efficiency (RTE) results showed that all 12 chemical components targeted the kidney and sexual organs.
The results indicated that the Eucommiae Cortex and Psoraleae Fructus after salt-processing could significantly increase the distribution of components to the kidney and generative organs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hou, Jingxia& Lin, Shangyang& Lu, Jinlan& Wu, Yu& Wu, Li& Chen, Zhipeng…[et al.]. 2020. Establishment of a UPLC-MSMS Method for Studying the Effect of Salt-Processing on Tissue Distribution of Twelve Major Bioactive Components of Qing’e Pills in Rats. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1174922
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hou, Jingxia…[et al.]. Establishment of a UPLC-MSMS Method for Studying the Effect of Salt-Processing on Tissue Distribution of Twelve Major Bioactive Components of Qing’e Pills in Rats. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1174922
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hou, Jingxia& Lin, Shangyang& Lu, Jinlan& Wu, Yu& Wu, Li& Chen, Zhipeng…[et al.]. Establishment of a UPLC-MSMS Method for Studying the Effect of Salt-Processing on Tissue Distribution of Twelve Major Bioactive Components of Qing’e Pills in Rats. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1174922
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174922
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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