The Involvement of Notch1-RBP-JkMsx2 Signaling Pathway in Aortic Calcification of Diabetic Nephropathy Rats
المؤلفون المشاركون
Wu, Weihua
Li, Li
Liu, Qi
Gan, Linwang
Ou, Santao
Gong, Caipan
Qin, Chunmei
Li, Ying
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
This study explored the changes in expression of vascular smooth muscle cell (VSMC) markers and osteogenic markers, as well as the involvement of Notch1-RBP-Jk/Msx2 pathway in a rat model of diabetic nephropathy (DN) with vascular calcification.
Methods.
A rat model of DN with concomitant vascular calcification was created by intraperitoneal injection of streptozotocin followed by administration of vitamin D3 and nicotine.
Biochemical analysis and histological examination of aortic tissue were performed.
VSMC markers and osteogenic markers as well as target molecules in Notch1-RBP-Jk/Msx2 were determined by quantitative real-time polymerase chain reaction and immunohistochemical analysis.
Results.
Serum calcium and phosphorus levels were significantly increased in model rats as compared to that in normal controls.
Diabetic rats with vascular calcification exhibited mineral deposits in aortic intima-media accompanied by decreased expression of VSMC markers and increased expression of osteogenic markers.
Notch1, RBP-Jk, Msx2, Jagged1, and N1-ICD were barely expressed in the aortic wall of normal rats.
In contrast, these were significantly increased in the model group at all time points (8, 12, and 16 weeks), as compared to that in the normal rats.
Conclusion.
Activation of the Notch1-RBP-Jk/Msx2 signaling pathway may be involved in the development and progression of vascular calcification in DN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gong, Caipan& Li, Li& Qin, Chunmei& Wu, Weihua& Liu, Qi& Li, Ying…[et al.]. 2017. The Involvement of Notch1-RBP-JkMsx2 Signaling Pathway in Aortic Calcification of Diabetic Nephropathy Rats. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174979
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gong, Caipan…[et al.]. The Involvement of Notch1-RBP-JkMsx2 Signaling Pathway in Aortic Calcification of Diabetic Nephropathy Rats. Journal of Diabetes Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1174979
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gong, Caipan& Li, Li& Qin, Chunmei& Wu, Weihua& Liu, Qi& Li, Ying…[et al.]. The Involvement of Notch1-RBP-JkMsx2 Signaling Pathway in Aortic Calcification of Diabetic Nephropathy Rats. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174979
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174979
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر