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Prevalence of Positive Diabetes-Associated Autoantibodies among Type 2 Diabetes and Related Metabolic and Inflammatory Differences in a Sample of the Bulgarian Population
المؤلفون المشاركون
Zaharieva, Emanuela Tsvetkova
Velikova, Tsvetelina Veselinova
Tsakova, Adelina Dimitrova
Kamenov, Zdravko A.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The study aimed to estimate the prevalence of unrecognized cases with positive autoantibodies among type 2 diabetes (T2D) in a sample of the Bulgarian population and to compare some metabolic and inflammatory markers to those of patients having negative autoantibodies and subjects with latent autoimmune diabetes (LADA).
Methods.
Patients with T2D, patients with LADA, and control participants were enrolled.
Antiglutamic acid decarboxylase, anti-insulinoma-associated 2, and antizinc transporter 8 autoantibodies were assayed through ELISA.
C-reactive protein and interleukin 6 (IL-6) and tumor necrosis factor alpha were assessed.
Results.
Ten percent of patients with T2D had positive autoantibodies.
They had lower body mass index (p=0.014), worse glycemic control (HbA1c, p=0.033), and better HDL cholesterol (p=0.026) than those in negative autoantibodies cases.
Compared to LADA, glycemia and anthropometric data did not differ significantly but metabolic syndrome was more prevalent among newly found cases with positive autoantibodies (p=0.046).
Their level of inflammatory markers was similar to that of patients having negative autoantibodies (p>0.05), but IL-6 was higher when compared to LADA (p=0.002).
Conclusion.
Prevalence of patients having positive autoantibodies within T2D in the analyzed sample of the Bulgarian population was 10%.
They shared common metabolic features with subjects with LADA, but inflammatory phenotype was closer to that of T2D.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zaharieva, Emanuela Tsvetkova& Velikova, Tsvetelina Veselinova& Tsakova, Adelina Dimitrova& Kamenov, Zdravko A.. 2017. Prevalence of Positive Diabetes-Associated Autoantibodies among Type 2 Diabetes and Related Metabolic and Inflammatory Differences in a Sample of the Bulgarian Population. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1175002
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zaharieva, Emanuela Tsvetkova…[et al.]. Prevalence of Positive Diabetes-Associated Autoantibodies among Type 2 Diabetes and Related Metabolic and Inflammatory Differences in a Sample of the Bulgarian Population. Journal of Diabetes Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1175002
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zaharieva, Emanuela Tsvetkova& Velikova, Tsvetelina Veselinova& Tsakova, Adelina Dimitrova& Kamenov, Zdravko A.. Prevalence of Positive Diabetes-Associated Autoantibodies among Type 2 Diabetes and Related Metabolic and Inflammatory Differences in a Sample of the Bulgarian Population. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1175002
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175002
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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