The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration
المؤلفون المشاركون
Claus Peter, Schmitt
Yard, Benito A.
Bakker, Stephan J. L.
van den Born, Jaap
Hauske, Sibylle J.
Qiu, Jiedong
Albrecht, Thomas
Zhang, Shiqi
Braun, Jana D.
Xia, Li
Rodriquez, Angelica
Peters, Verena
Lammert, Alexander
Köppel, Hannes
Schnuelle, Peter
Krämer, Bernhard K.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Considering that the homozygous CNDP1 (CTG)5 genotype affords protection against diabetic nephropathy (DN) in female patients with type 2 diabetes, this study assessed if this association remains gender-specific when applying clinical inclusion criteria (CIC-DN) or biopsy proof (BP-DN).
Additionally, it assessed if the prevalence of the protective genotype changes with diabetes duration and time on hemodialysis and if this occurs in association with serum carnosinase (CN-1) activity.
Whereas the distribution of the (CTG)5 homozygous genotype in the no-DN and CIC-DN patients was comparable, a lower frequency was found in the BP-DN patients, particularly in females.
We observed a significant trend towards high frequencies of the (CTG)5 homozygous genotype with increased time on dialysis.
This was also observed for diabetes duration but only reached significance when both (CTG)5 homo- and heterozygous patients were included.
CN-1 activity negatively correlated with time on hemodialysis and was lower in (CTG)5 homozygous patients.
The latter remained significant in female subjects after gender stratification.
We confirm the association between the CNDP1 genotype and DN to be likely gender-specific.
Although our data also suggest that (CTG)5 homozygous patients may have a survival advantage on dialysis and in diabetes, this hypothesis needs to be confirmed in a prospective cohort study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Albrecht, Thomas& Zhang, Shiqi& Braun, Jana D.& Xia, Li& Rodriquez, Angelica& Qiu, Jiedong…[et al.]. 2017. The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1175024
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Albrecht, Thomas…[et al.]. The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration. Journal of Diabetes Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1175024
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Albrecht, Thomas& Zhang, Shiqi& Braun, Jana D.& Xia, Li& Rodriquez, Angelica& Qiu, Jiedong…[et al.]. The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1175024
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175024
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر