Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults
المؤلفون المشاركون
Nóbrega, Otávio Toledo
Morais Junior, Gilberto Santos
Viana, Nayara I.
Reis, Sabrina T.
Perez, Diego I. V.
Freitas, Wladimir M.
Sposito, Andrei C.
Leite, Kátia R. M.
Srougi, Miguel
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-24
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
The human aging is marked by several body changes, including in bone mineral density (BMD).
Research shows that microRNAs are important modulators of bone metabolism.
The present research aims to analyze the whole blood concentration of 10 selected microRNAs (miRs) and their association with absolute and relative scores of BMD in specific osseous site of Brazilian very-old adults.
Forty noninstitutionalized and apparently healthy, very old (≥80 years) outpatients were eligible for research.
Anthropometry, biochemistry, and densitometry measurements were performed along with coronary artery calcification (CAC) scores and tested across total circulating levels of microRNAs.
As expected, the relative BMD scores for the lumbosacral region (L1 to S5) and for the femoral head and neck observed in the sample denote weakened bone architecture, compatible with prevalent osteopenia and osteoporosis.
In this context, one single significant association was found, and negatively implicated the miR-34a-5p with both absolute (β = −0.36, P=0.001 for BMD) and relative (β = −0.43, P=0.001 for T-score) densitometry indexes of the femoral head (adjusted to sex and physical activity practice), but not with the other sites.
No difference in total blood concentrations of the miRs was found according to CAC scores.
Our findings indicate greater circulating levels for miR-34a-5p among very-old adults who display the lowest scores of BMD, being a finding consistent with a modest contribution of the miR (along with co-variables) to the mineralization of that site.
Attesting clinical relevance of our findings demands forthcoming studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nóbrega, Otávio Toledo& Morais Junior, Gilberto Santos& Viana, Nayara I.& Reis, Sabrina T.& Perez, Diego I. V.& Freitas, Wladimir M.…[et al.]. 2020. Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults. Journal of Aging Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1175079
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nóbrega, Otávio Toledo…[et al.]. Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults. Journal of Aging Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1175079
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nóbrega, Otávio Toledo& Morais Junior, Gilberto Santos& Viana, Nayara I.& Reis, Sabrina T.& Perez, Diego I. V.& Freitas, Wladimir M.…[et al.]. Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults. Journal of Aging Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1175079
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175079
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر