Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults
المؤلفون المشاركون
Santos Morais Junior, Gilberto
Ignacio Valenzuela Perez, Diego
Cecília Tonet-Furioso, Audrey
Gomes, Lucy
Coelho Vilaça, Karla Helena
Paulo Alves, Vicente
Franco Moraes, Clayton
Toledo Nóbrega, Otávio
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-04
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Background and Aim.
Frailty is a geriatric condition resulting from physiological changes covering the musculoskeletal, immune, and neuroendocrine systems, leading to a greater inflammatory state.
The present research aimed to investigate the association of components of Fried’s frailty (as well as of the phenotype as a whole) with total serum levels of a panel of inflammatory mediators.
Methods.
One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses.
Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators (IFNγ, IL-2, IL-4, IL-6, IL-10, and TNFα) were assessed using high-throughput flow cytometry.
Results.
Preliminarily, IL-6 correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia.
In analyses controlled for these factors, serum levels of IL-6 were comparatively augmented among the very old participants with reduced grip strength (OR = 3.299; 95% CI 1.08–6.09; p=0.032) and among those with slow walk speed (OR = 2.460; 95% CI 1.16–7.05; p=0.022).
Conclusions.
Our study shows a strong negative correlation of IL-6 levels with Fried’s frailty components of grip strength and walk speed in very old adults, regardless of confounding factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santos Morais Junior, Gilberto& Ignacio Valenzuela Perez, Diego& Cecília Tonet-Furioso, Audrey& Gomes, Lucy& Coelho Vilaça, Karla Helena& Paulo Alves, Vicente…[et al.]. 2020. Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults. Journal of Aging Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1175122
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santos Morais Junior, Gilberto…[et al.]. Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults. Journal of Aging Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1175122
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santos Morais Junior, Gilberto& Ignacio Valenzuela Perez, Diego& Cecília Tonet-Furioso, Audrey& Gomes, Lucy& Coelho Vilaça, Karla Helena& Paulo Alves, Vicente…[et al.]. Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults. Journal of Aging Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1175122
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175122
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر