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Age- and Organ-Specific Differences in Mitochondrial Bioenergetics in Brown Norway Rats
المؤلفون المشاركون
Pandya, Jignesh D.
Valdez, Matthew
Royland, Joyce E.
MacPhail, Robert C.
Sullivan, Patrick G.
Kodavanti, Prasada Rao S.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-01
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Mitochondria play a central role in energy homeostasis and act as regulatory checkpoints for downstream metabolic responses and cell senescence processes during an entire life span.
Acute or chronic environmental toxicant exposures have shown deleterious organ-specific human health issues at various life stages.
Since mitochondria are a prime target for ensuing cellular bioenergetics responses and senescence, it is essential to understand mitochondrial bioenergetic responses in different organs over multiple life stages.
Therefore, in the present study, we evaluated mitochondrial bioenergetic parameters in the liver, lung, and heart in four diverse age groups (young: 1 month; adult: 4 months; middle-aged: 12 months; old-aged: 24 month) using male Brown Norway rats as a model of aging (n = 5 sample size/organ/age group) and compared them with our previously published results on brain.
Real-time mitochondrial bioenergetic parameters (i.e., State III, State IV, and State V) were measured using the Seahorse Extracellular Flux Analyzer.
Additionally, mitochondrial enzyme pyruvate dehydrogenase complex (PDHC), Complex I, Complex II, and Complex IV activities were measured using Synergy HT plate reader.
Our results indicated that nearly in all parameters, significant age- and organ-specific interactions were observed.
We observed age-specific declines in State III (i.e., ATP synthesis rate) responses in both the heart and lung, where opposite was observed in the liver as age advances.
Across the age, the heart has highest enzyme activities than the liver and lung.
Interestingly, heart and liver mitochondrial bioenergetic rates and enzyme activities remain higher than the lung, which specifies their higher metabolic capabilities than the lung.
Amongst all, bioenergetic rates and enzyme activities in the lung remain lowest suggesting the lung may display higher vulnerability and lower resilience to environmental toxicants during aging than other organs tested here.
Overall, these age- and organ-specific findings may facilitate a more contextualized understanding of mitochondrial bioenergetic outcomes when considering the interactions of age-related sensitivities with exposure to chemical stressors from the environment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pandya, Jignesh D.& Valdez, Matthew& Royland, Joyce E.& MacPhail, Robert C.& Sullivan, Patrick G.& Kodavanti, Prasada Rao S.. 2020. Age- and Organ-Specific Differences in Mitochondrial Bioenergetics in Brown Norway Rats. Journal of Aging Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1175127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pandya, Jignesh D.…[et al.]. Age- and Organ-Specific Differences in Mitochondrial Bioenergetics in Brown Norway Rats. Journal of Aging Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1175127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pandya, Jignesh D.& Valdez, Matthew& Royland, Joyce E.& MacPhail, Robert C.& Sullivan, Patrick G.& Kodavanti, Prasada Rao S.. Age- and Organ-Specific Differences in Mitochondrial Bioenergetics in Brown Norway Rats. Journal of Aging Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1175127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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