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Population-Wide Associations between Common Viral Pathogens and Self-Reported Arthritis: NHANES 2009-2012
المؤلفون المشاركون
Shmagel, Anna
Skemp-Dymond, Grace
Langsetmo, Lisa
Schousboe, John T.
Ensrud, Kristine
Foley, Robert
المصدر
International Journal of Rheumatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Persistent infectious agents have been implicated in chronic and recurrent inflammation, which may trigger or worsen many types of arthritis.
Our objective was to determine whether exposure to herpes simplex virus (HSV) and human papillomavirus (HPV) is associated with self-reported arthritis among US adults.
Methods.
We used data from two consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) from 2009 until 2012 (N of examined adults ages 20-69 = 9483).
Participants were classified as having arthritis by self-report.
Viral serology for HSV-1 and HSV-2 and HPV PCR studies from oral rinse and vaginal swabs were available for analysis.
We compared HSV-1 and HSV-2 seropositivity as well as oral and vaginal HPV DNA positivity between participants with self-reported arthritis vs.
those without, adjusting for age, gender, race, income, education, BMI, and the use of immunosuppressive medications.
We used three comparator outcomes, gout, kidney stones, and hypertension, to evaluate whether the associations were specific or not to arthritis.
Results.
Arthritis was associated with older age, female gender, non-Hispanic White and Non-Hispanic Black race, higher BMI, and lower socioeconomic status.
HSV-2 seropositivity, but not HSV-1 seropositivity, was independently associated with arthritis after adjustment for age, gender, race, income, education, BMI, and the use of immunosuppressive medications: AOR 1.48 (1.10-1.99).
Oral HPV DNA positivity was also independently associated with arthritis: AOR 1.63 (1.17-2.28).
After adjustment, there was no statistically significant difference in vaginal HPV DNA positivity between those with vs.
those without arthritis: AOR 1.22 (0.90-1.66).
There were no significant associations between viral exposures and any of the comparator outcomes.
Conclusions.
HSV-2 seropositivity and oral HPV DNA positivity were associated with self-reported arthritis and not with comparator outcomes, after adjustment for multiple potential confounders.
These findings should be confirmed in longitudinal studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shmagel, Anna& Skemp-Dymond, Grace& Langsetmo, Lisa& Schousboe, John T.& Ensrud, Kristine& Foley, Robert. 2018. Population-Wide Associations between Common Viral Pathogens and Self-Reported Arthritis: NHANES 2009-2012. International Journal of Rheumatology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1175483
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shmagel, Anna…[et al.]. Population-Wide Associations between Common Viral Pathogens and Self-Reported Arthritis: NHANES 2009-2012. International Journal of Rheumatology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1175483
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shmagel, Anna& Skemp-Dymond, Grace& Langsetmo, Lisa& Schousboe, John T.& Ensrud, Kristine& Foley, Robert. Population-Wide Associations between Common Viral Pathogens and Self-Reported Arthritis: NHANES 2009-2012. International Journal of Rheumatology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1175483
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175483
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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