HLA Polymorphisms and Haplotype Diversity in Transylvania, Romania
المؤلفون المشاركون
Bondor, Cosmina I.
Vică, Mihaela L.
Matei, Horea V.
Nicula, Gheorghe Z.
Siserman, Costel V.
Loga, Luminița
Dican, Lucia
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Transylvania is a historical region in the northwestern part of Romanian with a rather heterogeneous population.
Our study is the first to determine human leukocyte antigen (HLA) profiles in a large population sample from this region and to compare them with other European population groups.
HLA genes were examined in 2,794 individuals using the Single Specific Primer-Polymerase Chain Reaction (SSP-PCR) and Polymerase Chain Reaction Sequence-Specific Oligonucleotide (PCR-SSO) methods.
All samples were tested for the HLA-A locus, 2,773 for HLA-B, 1,847 for HLA-C, and 2,719 for HLA-DRB1 loci.
HLA gene frequency data from several European population groups (as presented in studies involving more than 1,000 individuals) served as reference in comparison with the local sample.
The distribution of HLA genes in the studied population group was heterogeneous, as the Hardy-Weinberg equilibrium was statistically significant (P value < 0.01).
The most common genes found in our sample group were A∗02 (0.27%), B∗35 (0.14%), C∗07 (0.25%), and DRB1∗11 (0.19%).
The most common haplotype was A∗01~B∗08~C∗07~DRB1∗03 (1.26% in 1,770 individuals with complete data).
This analysis confirmed the known heterogeneity of the Transylvanian population.
The study indicates that the European population groups located in close vicinity (those from Serbia, Hungary, Wallachia, and Croatia) are genetically closest to the Transylvanian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vică, Mihaela L.& Matei, Horea V.& Bondor, Cosmina I.& Nicula, Gheorghe Z.& Siserman, Costel V.& Loga, Luminița…[et al.]. 2019. HLA Polymorphisms and Haplotype Diversity in Transylvania, Romania. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1175667
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vică, Mihaela L.…[et al.]. HLA Polymorphisms and Haplotype Diversity in Transylvania, Romania. Journal of Immunology Research No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1175667
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vică, Mihaela L.& Matei, Horea V.& Bondor, Cosmina I.& Nicula, Gheorghe Z.& Siserman, Costel V.& Loga, Luminița…[et al.]. HLA Polymorphisms and Haplotype Diversity in Transylvania, Romania. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1175667
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175667
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر