Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure

المؤلفون المشاركون

Peng, Liang
Gao, Zhiliang
Zhao, Qiyi
Zhang, Geng-lin
Zhang, Ting
Xie, Chan

المصدر

Journal of Immunology Research

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-05-06

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأحياء

الملخص EN

Background and Aims.

Serum immunoglobulins are frequently increased in patients with chronic liver disease, but little is known about the role of serum immunoglobulins and their correlations with interleukin-27 (IL-27) in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF).

This study was aimed at determining the role of serum immunoglobulin (IgG, IgA, and IgM) levels and their associations with IL-27 in noncirrhotic patients with HBV-ACLF.

Methods.

Samples were assessed from thirty patients with HBV-ACLF, twenty-four chronic hepatitis B (CHB) subjects, and eighteen normal controls.

Disease severity of HBV-ACLF was evaluated.

Serum IL-27 levels were examined by enzyme-linked immunosorbent assay.

Immunoglobulin levels were assessed using immunoturbidimetric assay.

Correlations between immunoglobulin levels and IL-27 were analyzed.

Receiver operating characteristic (ROC) curves were used to predict the 3-month mortality.

Results.

25 (83.3%) HBV-ACLF patients had elevated serum IgG levels (>1 ULN), 14 (46.7%) patients had elevated IgA, and 15 (50%) had raised IgM.

IgG, IgA, and IgM levels were higher in HBV-ACLF patients than in CHB patients and normal controls.

Moreover, IgG, IgA, and IgM levels were positively correlated with Tbil levels but negatively correlated with prothrombin time activity (PTA) levels.

Additionally, IgG levels were significantly increased in nonsurviving patients than in surviving HBV-ACLF patients (P=0.007) and positively correlated with MELD score (r=0.401, P=0.028).

Also, IgG levels were positively correlated with IL-27 levels in HBV-ACLF patients (r=0.398, P=0.029).

Furthermore, ROC curve showed that IgG levels could predict the 3-month mortality in HBV-ACLF patients (the area under the ROC curve: 0.752, P=0.005).

Conclusions.

Our findings demonstrated that serum immunoglobulins were preferentially elevated in HBV-ACLF patients.

IgG levels were positively correlated with IL-27 and may predict prognosis in HBV-ACLF patients.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Geng-lin& Zhao, Qiyi& Xie, Chan& Peng, Liang& Zhang, Ting& Gao, Zhiliang. 2019. Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1175697

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Geng-lin…[et al.]. Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1175697

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Geng-lin& Zhao, Qiyi& Xie, Chan& Peng, Liang& Zhang, Ting& Gao, Zhiliang. Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1175697

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1175697