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The Functions and Mechanism of a New Oligopeptide BP9 from Avian Bursa on Antibody Responses, Immature B Cell, and Autophagy
المؤلفون المشاركون
Feng, Xiu Li
Zong, Man Man
Zhou, Guang Fang
Zheng, Yang
Yu, Yuan Nan
Cao, Rui Bing
Chen, Pu Yan
Yang, Mei
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-06
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The bursa of Fabricius is an acknowledged central humoral immune organ unique to birds, which is vital to B cell differentiation and antibody production.
However, the function and mechanism of the biological active peptide isolated from bursa on B cell development and autophagy were less reported.
In this study, we isolated a new oligopeptide with nine amino acids Leu-Met-Thr-Phe-Arg-Asn-Glu-Gly-Thr from avian bursa following RP-HPLC, MODIL-TOP-MS, and MS/MS, which was named after BP9.
The results of immunization experiments showed that mice injected with 0.01 and 0.05 mg/mL BP9 plus JEV vaccine generated the significant increased antibody levels, compared to those injected with JEV vaccine only.
The microarray analysis on the molecular basis of BP9-treated immature B cell showed that vast genes were involved in various immune-related biological processes in BP9-treated WEHI-231 cells, among which the regulation of cytokine production and T cell activation were both major immune-related processes in WEHI-231 cells with BP9 treatment following network analysis.
Also, the differentially regulated genes were found to be involved in four significantly enriched pathways in BP9-treated WEHI-231 cells.
Finally, we proved that BP9 induced the autophagy formation, regulated the gene and protein expressions related to autophagy in immature B cell, and stimulated AMPK-ULK1 phosphorylation expression.
These results suggested that BP9 might be a strong bursal-derived active peptide on antibody response, B cell differentiation, and autophagy in immature B cells, which provided the linking among humoral immunity, B cell differentiation, and autophagy and offered the important reference for the effective immunotherapeutic strategies and immune improvement.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Feng, Xiu Li& Zong, Man Man& Zhou, Guang Fang& Zheng, Yang& Yu, Yuan Nan& Cao, Rui Bing…[et al.]. 2019. The Functions and Mechanism of a New Oligopeptide BP9 from Avian Bursa on Antibody Responses, Immature B Cell, and Autophagy. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1175703
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feng, Xiu Li…[et al.]. The Functions and Mechanism of a New Oligopeptide BP9 from Avian Bursa on Antibody Responses, Immature B Cell, and Autophagy. Journal of Immunology Research No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1175703
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Feng, Xiu Li& Zong, Man Man& Zhou, Guang Fang& Zheng, Yang& Yu, Yuan Nan& Cao, Rui Bing…[et al.]. The Functions and Mechanism of a New Oligopeptide BP9 from Avian Bursa on Antibody Responses, Immature B Cell, and Autophagy. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1175703
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175703
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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