Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy
المؤلفون المشاركون
Shenoy, Ashok K.
Chowta, Mukta N.
Kamath, Priyanka
Ramapuram, John T.
Hadigal, Sanjay
المصدر
Interdisciplinary Perspectives on Infectious Diseases
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Objectives.
The objective was to study the adverse drug reaction (ADR) profile in HIV patients receiving first-line antiretroviral therapy.
Methods.
This was a prospective, observational study that included 171 HIV patients with a follow-up at six months.
Demographic details, medical history, details of HIV infection including most recent CD4 count, details of antiretroviral therapy, and other concomitant medication were recorded.
Adverse drug reactions were elicited by reviewing patient records and also by interviewing the patient/attendants directly.
Results.
171 patients completed the study out of which 88 (51.5%) were males and 83 (48.5%) were females.
The study subjects included HIV-positive, treatment naïve patients who were started on treatment regimens recommended by the NACO guidelines.
The ADRs observed were a fall in haemoglobin or absolute anaemia in response to zidovudine, nonspecific symptoms like headache, and a nonspecific feeling of being unwell in response to tenofovir, stavudine, and efavirenz; dyslipidaemia, pancreatitis, peripheral neuropathy, and lactic acidosis in response to stavudine; generalised rash in response to nevirapine and one case of nephrotoxicity to efavirenz.
Majority of the ADRs satisfied the ‘probable’ category (60.1%), and the rest were “possible”.
ADRs to zidovudine and nevirapine superseded all others.
Interpretation and Conclusion.
Gastrointestinal effects were the most commonly observed group of ADRs, with nausea being the most common ADR, the others being gastritis and diarrhoea.
The other ADRs included rash, hepatotoxicity, blood dyscrasias like anaemia, neutropenia, and thrombocytopenia, and fatigue.
Few cases of lactic acidosis, peripheral neuropathy, headache, lipoatrophy, and pancreatitis were reported.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chowta, Mukta N.& Kamath, Priyanka& Ramapuram, John T.& Shenoy, Ashok K.& Hadigal, Sanjay. 2018. Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1175867
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chowta, Mukta N.…[et al.]. Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy. Interdisciplinary Perspectives on Infectious Diseases No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1175867
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chowta, Mukta N.& Kamath, Priyanka& Ramapuram, John T.& Shenoy, Ashok K.& Hadigal, Sanjay. Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy. Interdisciplinary Perspectives on Infectious Diseases. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1175867
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175867
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر