Taenia crassiceps-ExcretedSecreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages
المؤلفون المشاركون
Satoskar, Abhay R.
Callejas, Blanca E.
Terrazas, César A.
Martínez-Saucedo, Diana
Partida-Sánchez, Santiago
Ruíz-Rosado, Juan de Dios
Terrazas, Luis I.
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-14
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
Helminth parasites modulate immune responses in their host to prevent their elimination and to establish chronic infections.
Our previous studies indicate that Taenia crassiceps-excreted/secreted antigens (TcES) downregulate inflammatory responses in rodent models of autoimmune diseases, by promoting the generation of alternatively activated-like macrophages (M2) in vivo.
However, the molecular mechanisms triggered by TcES that modulate macrophage polarization and inflammatory response remain unclear.
Here, we found that, while TcES reduced the production of inflammatory cytokines (IL-6, IL-12, and TNFα), they increased the release of IL-10 in LPS-induced bone marrow-derived macrophages (BMDM).
However, TcES alone or in combination with LPS or IL-4 failed to increase the production of the canonical M1 or M2 markers in BMDM.
To further define the anti-inflammatory effect of TcES in the response of LPS-stimulated macrophages, we performed transcriptomic array analyses of mRNA and microRNA to evaluate their levels.
Although the addition of TcES to LPS-stimulated BMDM induced modest changes in the inflammatory mRNA profile, it induced the production of mRNAs associated with the activation of different receptors, phagocytosis, and M2-like phenotype.
Moreover, we found that TcES induced upregulation of specific microRNAs, including miR-125a-5p, miR-762, and miR-484, which are predicted to target canonical inflammatory molecules and pathways in LPS-induced BMDM.
These results suggest that TcES can modulate proinflammatory responses in macrophages by inducing regulatory posttranscriptional mechanisms and hence reduce detrimental outcomes in hosts running with inflammatory diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martínez-Saucedo, Diana& Ruíz-Rosado, Juan de Dios& Terrazas, César A.& Callejas, Blanca E.& Satoskar, Abhay R.& Partida-Sánchez, Santiago…[et al.]. 2019. Taenia crassiceps-ExcretedSecreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-24.
https://search.emarefa.net/detail/BIM-1175929
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martínez-Saucedo, Diana…[et al.]. Taenia crassiceps-ExcretedSecreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. Journal of Immunology Research No. 2019 (2019), pp.1-24.
https://search.emarefa.net/detail/BIM-1175929
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martínez-Saucedo, Diana& Ruíz-Rosado, Juan de Dios& Terrazas, César A.& Callejas, Blanca E.& Satoskar, Abhay R.& Partida-Sánchez, Santiago…[et al.]. Taenia crassiceps-ExcretedSecreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-24.
https://search.emarefa.net/detail/BIM-1175929
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175929
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر