Tissue-Specific Autoantibodies Improve Diagnosis of Primary Sjögren’s Syndrome in the Early Stage and Indicate Localized Salivary Injury
المؤلفون المشاركون
Sun, Xiaolin
Li, Zhanguo
He, Jing
Jin, Yuebo
Li, Jing
Chen, Jiali
Shao, Miao
Zhang, Ruijun
Liang, Yichen
Zhang, Xia
Zhang, Xiaoying
Zhang, Qin
Li, Fangting
Cheng, Yaobin
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands.
Due to the absence of specific clinical manifestations and biomarkers in the early stage, pSS is generally underrecognized.
To elucidate the role of the tissue-specific autoantibodies (TSAs), i.e., anti-CA6, anti-SP1, and anti-PSP antibodies, we enrolled 137 pSS patients, 32 secondary Sjögren’s syndrome (sSS) patients, and 127 healthy controls (HCs), whose serum and saliva samples were collected.
TSA levels were detected by ELISA, and the clinical and laboratory data was reviewed from the medical records.
The analysis results showed the following: (1) Compared to HCs, the serum IgA levels of anti-CA6, anti-SP1 and anti-PSP were significantly higher in pSS as well as in sSS patients, and anti-CA6 IgG was also notably higher in pSS patients.
(2) The positivity of anti-CA6, anti-PSP and all the three antibodies together were significantly increased in anti-SSA-negative pSS patients.
(3) The average IgM levels of anti-CA6 and anti-SP1 decreased as the disease duration extended.
(4) The anti-CA6-positive patients have significantly higher levels of serum IgA, while the anti-PSP-positive group has a notably higher serum IgM level.
(5) Another autoantibody specific to the salivary glands, anti-α-fodrin antibody, was elevated in TSA-positive patients, especially in the anti-CA6-positive group.
(6) Preliminary detection of saliva TSAs showed that all the IgG levels of these three antibodies increased significantly in pSS patients.
In conclusion, TSAs improve diagnosis of pSS in the early stage, especially in anti-SSA-negative patients, and their tissue-specific nature indicates localized salivary injury, which deserves further studies to clarify the mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Yuebo& Li, Jing& Chen, Jiali& Shao, Miao& Zhang, Ruijun& Liang, Yichen…[et al.]. 2019. Tissue-Specific Autoantibodies Improve Diagnosis of Primary Sjögren’s Syndrome in the Early Stage and Indicate Localized Salivary Injury. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1176084
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Yuebo…[et al.]. Tissue-Specific Autoantibodies Improve Diagnosis of Primary Sjögren’s Syndrome in the Early Stage and Indicate Localized Salivary Injury. Journal of Immunology Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1176084
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Yuebo& Li, Jing& Chen, Jiali& Shao, Miao& Zhang, Ruijun& Liang, Yichen…[et al.]. Tissue-Specific Autoantibodies Improve Diagnosis of Primary Sjögren’s Syndrome in the Early Stage and Indicate Localized Salivary Injury. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1176084
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176084
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر