Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response

المؤلفون المشاركون

Cabrera, Wafa H. K.
Ribeiro, Orlando G.
Jensen, José Ricardo
Ibañez, Olga M.
Starobinas, Nancy
Borrego, Andrea
De Franco, Marcelo
de Carvalho, Lilian Rego
Santos, Aline Marques
Dragani, Tommaso A.
Manenti, Giacomo

المصدر

Journal of Immunology Research

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-03-31

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأحياء

الملخص EN

AIRmax and AIRmin mouse strains phenotypically selected for high and low acute inflammatory responsiveness (AIR) are, respectively, susceptible or resistant to developing hepatocellular carcinoma (HCC) induced by the chemical carcinogens urethane and diethylnitrosamine (DEN).

Early production of TNF-α, IL-1β, and IL-6 in the liver after DEN treatment correlated with tumor development in AIRmax mice.

Transcriptome analysis of livers from untreated AIRmax and AIRmin mice showed specific gene expression profiles in each line, which might play a role in their differential susceptibility to HCC.

Linkage analysis with SNP markers in F2 (AIRmax×AIRmin) intercross mice revealed two quantitative trait loci (QTL) in chromosomes 2 and 9, which are significantly associated with the number and progression of urethane-induced liver tumors.

An independent linkage analysis with an intercross population from A/J and C57BL/6J inbred mice mapped regions in chromosomes 1 and 7 associated with the progression of urethane-induced liver tumors, evidencing the heterogeneity of HCC genetic control.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

de Carvalho, Lilian Rego& Borrego, Andrea& Jensen, José Ricardo& Cabrera, Wafa H. K.& Santos, Aline Marques& Ribeiro, Orlando G.…[et al.]. 2019. Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1176314

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

de Carvalho, Lilian Rego…[et al.]. Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1176314

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

de Carvalho, Lilian Rego& Borrego, Andrea& Jensen, José Ricardo& Cabrera, Wafa H. K.& Santos, Aline Marques& Ribeiro, Orlando G.…[et al.]. Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1176314

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1176314