Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MSMS after Oral Administration of Drynariae rhizoma Extract
المؤلفون المشاركون
Liu, Ming-Yang
Zhang, Ning
Geng, Fang
Xu, Zhan-Ling
Xu, Ming-Yue
Wang, Hai-Tao
Xu, Qing-Xuan
Jia, Chun-Peng
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
As a traditional Chinese medicine, Drynariae rhizoma (Kunze ex Mett.) J.
Sm.
has been used to treat osteoporosis and bone resorption for 2500 years.
Based on the previous study and literature references, flavonoids were proved to be the most abundant and main active compounds of Drynariae rhizoma for osteoporosis treatment.
In order to make good and rational use of Drynariae rhizoma in future, a rapid, sensitive, and selective ultraperformance liquid chromatography-mass spectrometry (UPLC-MS/MS) method was developed to investigate the pharmacokinetics of eight main flavonoids in rat plasma after oral administration of the Drynariae rhizoma extract, including neoeriocitrin, luteolin-7-O-β-D-glucoside, astragalin, naringin, eriodictyol, luteolin, naringenin, and kaempferol.
Plasma samples’ pretreatment involved a solid-phase extraction column.
The separation was performed on an ACQUITY UPLCTM BEH C18 column with a gradient mobile-phase system of acetonitrile and 1% acetic acid in water.
The detection was performed using a triple quadrupole tandem mass spectrometer equipped with an electrospray ionization interface (ESI) by multiple reaction monitoring (MRM) in the positive ion mode.
All calibration curves exhibited good linearity (r2 > 0.9990) over the measured ranges.
The intraday and interday precisions (RSD) were within 13.87%, and the accuracy (RE) ranged from −14.57% to −0.25% at three quality control levels.
Extraction recovery, matrix effect, and stability were satisfactory.
The pharmacokinetic characteristics of the eight flavonoids of interest were clearly elucidated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Zhan-Ling& Xu, Ming-Yue& Wang, Hai-Tao& Xu, Qing-Xuan& Liu, Ming-Yang& Jia, Chun-Peng…[et al.]. 2018. Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MSMS after Oral Administration of Drynariae rhizoma Extract. Journal of Analytical Methods in Chemistry،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1176378
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Zhan-Ling…[et al.]. Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MSMS after Oral Administration of Drynariae rhizoma Extract. Journal of Analytical Methods in Chemistry No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1176378
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Zhan-Ling& Xu, Ming-Yue& Wang, Hai-Tao& Xu, Qing-Xuan& Liu, Ming-Yang& Jia, Chun-Peng…[et al.]. Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MSMS after Oral Administration of Drynariae rhizoma Extract. Journal of Analytical Methods in Chemistry. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1176378
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176378
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر