Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent
المؤلفون المشاركون
Idosa, Berhane Asfaw
Kelly, Anne
Jacobsson, Susanne
Demirel, Isak
Fredlund, Hans
Särndahl, Eva
Persson, Alexander
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-06
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Meningococcal disease such as sepsis and meningitidis is hallmarked by an excessive inflammatory response.
The causative agent, Neisseria meningitidis, expresses the endotoxin lipooligosaccharide (LOS) that is responsible for activation of immune cells and the release of proinflammatory cytokines.
One of the most potent proinflammatory cytokines, interleukin-1β (IL-1β), is activated following caspase-1 activity in the intracellular multiprotein complex called inflammasome.
Inflammasomes are activated by a number of microbial factors as well as danger molecules by a two-step mechanism—priming and licensing of inflammasome activation—but there are no data available regarding a role for inflammasome activation in meningococcal disease.
The aim of this study was to investigate if N.
meningitidis activates the inflammasome and, if so, the role of bacterial LOS in this activation.
Cells were subjected to N.
meningitidis, both wild-type (FAM20) and its LOS-deficient mutant (lpxA), and priming as well as licensing of inflammasome activation was investigated.
The wild-type LOS-expressing parental FAM20 serogroup C N.
meningitidis (FAM20) strain significantly enhanced the caspase-1 activity in human neutrophils and monocytes, whereas lpxA was unable to induce caspase-1 activity as well as to induce IL-1β release.
While the lpxA mutant induced a priming response, measured as increased expression of NLRP3 and IL1B, the LOS-expressing FAM20 further increased this priming.
We conclude that although non-LOS components of N.
meningitidis contribute to the priming of the inflammasome activity, LOS per se is to be considered as the central component of N.
meningitidis virulence, responsible for both priming and licensing of inflammasome activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Idosa, Berhane Asfaw& Kelly, Anne& Jacobsson, Susanne& Demirel, Isak& Fredlund, Hans& Särndahl, Eva…[et al.]. 2019. Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176446
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Idosa, Berhane Asfaw…[et al.]. Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent. Journal of Immunology Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1176446
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Idosa, Berhane Asfaw& Kelly, Anne& Jacobsson, Susanne& Demirel, Isak& Fredlund, Hans& Särndahl, Eva…[et al.]. Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176446
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176446
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر