The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin
المؤلفون المشاركون
Lambropoulos, Alexandros
Papadopoulou-Alataki, Efimia
Karananou, Panagiota
Tramma, Despoina
Alataki, Anastasia
Katafigiotis, Socrates
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Urinary tract infections are one of the most common and serious bacterial infections in a pediatric population.
So far, they have mainly been related to age, gender, ethnicity, socioeconomic level, and the presence of underlying anatomical or functional, congenital, or acquired abnormalities.
Recently, both innate and adaptive immunities and their interaction in the pathogenesis and the development of UTIs have been studied.
The aim of this study was to assess the role and the effect of the two most frequent polymorphisms of TLR4 Asp299Gly and Thr399Ile on the development of UTIs in infants and children of Greek origin.
We studied 51 infants and children with at least one episode of acute urinary tract infection and 109 healthy infants and children.
We found that 27.5% of patients and 8.26% of healthy children carried the heterozygote genotype for TLR4 Asp299Gly.
TLR4 Thr399Ile polymorphism was found to be higher in healthy children and lower in the patient group.
No homozygosity for both studied polymorphisms was detected in our patients.
In the group of healthy children, a homozygote genotype for TLR4 Asp299Gly (G/G) as well as for TLR4 Thr399Ile (T/T) was showed (1.84% and 0.92 respectively).
These results indicate the role of TLR4 polymorphism as a genetic risk for the development of UTIs in infants and children of Greek origin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karananou, Panagiota& Tramma, Despoina& Katafigiotis, Socrates& Alataki, Anastasia& Lambropoulos, Alexandros& Papadopoulou-Alataki, Efimia. 2019. The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176538
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karananou, Panagiota…[et al.]. The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1176538
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karananou, Panagiota& Tramma, Despoina& Katafigiotis, Socrates& Alataki, Anastasia& Lambropoulos, Alexandros& Papadopoulou-Alataki, Efimia. The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176538
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176538
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر