Immunoregulatory Effects of Subcutaneous Immunotherapy on Lymphocyte Subgroups and Cytokines in Children with Asthma
المؤلفون المشاركون
Tian, Man
Zhou, Ying
Cui, Yubao
Chen, Meng
He, Yu-ting
Shao, Qi
Gan, Cong
Bao, Yu-ling
Gu, Hai-yan
Zhang, Shu-lan
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Asthma is a syndrome that incorporates many immune phenotypes.
The immunologic effects of subcutaneous immunotherapy (SCIT) exerts on allergic asthma remain still largely unknown.
Here, we investigated the effects of SCIT on cytokine production and peripheral blood levels of lymphocyte subtypes in children with mite-induced moderate and severe allergic asthma.
Methods.
The study included 60 kids with mite-induced allergic asthma from 5 to 10 years old.
All subjects had received antiasthmatic pharmacologic for 3 months at baseline.
Half of the children were treated with SCIT combined with pharmacologic treatment named the SCIT group and the other half only with pharmacologic therapy named the no-SCIT group.
Total asthma symptom score (TASS) and total medication score (TMS) were recorded.
Flow cytometry was used to identify lymphocyte subtypes: type 2 innate lymphocytes (ILC2s), type 1 (Th1) and type 2 (Th2) helper T cells, T helper 17 (Th17) cells, and regulatory T (Treg) cells.
ELISA, flow cytometry, and cytometric bead array were used to assess cytokines IL-13, IFN-γ, IL-4, IL-17, and TGF-β, at baseline and 3 and 6 months after study treatment in both groups of patients.
Results.
Both groups can significantly improve clinical symptoms in children with asthma.
SCIT can significantly reduce asthma medication after 6 months of treatment.
SCIT induced a significantly higher and progressive reduction in ILC2 percentage and IL-13 levels after 3 and 6 months of treatment compared with baseline and compared with no-SCIT patients.
Significant differences were detected in the Th1/Th2 cell ratio and IFN-γ/IL-4 cytokine ratio between groups after 6 months of treatment.
Similarly, the Th17/Treg ratio and IL-17/TGF-β ratio in the SCIT group were much lower than those in the no-SCIT group after 3-6 months of treatment.
Conclusion.
SCIT is a promising option to reduce the percentage of ILC2 and regulate Th1/Th2 and Th17/Treg immune balance in the peripheral blood of children with asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Yu-ting& Zhou, Ying& Shao, Qi& Gan, Cong& Chen, Meng& Bao, Yu-ling…[et al.]. 2019. Immunoregulatory Effects of Subcutaneous Immunotherapy on Lymphocyte Subgroups and Cytokines in Children with Asthma. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176601
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Yu-ting…[et al.]. Immunoregulatory Effects of Subcutaneous Immunotherapy on Lymphocyte Subgroups and Cytokines in Children with Asthma. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1176601
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Yu-ting& Zhou, Ying& Shao, Qi& Gan, Cong& Chen, Meng& Bao, Yu-ling…[et al.]. Immunoregulatory Effects of Subcutaneous Immunotherapy on Lymphocyte Subgroups and Cytokines in Children with Asthma. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176601
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176601
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر