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Decreased Expression of CD14 in MSU-Mediated Inflammation May Be Associated with Spontaneous Remission of Acute Gout
المؤلفون المشاركون
Duan, Lihua
Wang, Youlian
Fu, Qiang
Wei, Yingying
Luo, Jiao
Shang, Ke
Li, Yan
Chen, Jie
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Gout is a common metabolic disease in humans, and it is due to persistently elevated levels of uric acid in the blood.
At high levels, uric acid crystallizes and the crystals deposit in joints and surrounding tissues, resulting in an attack of gout.
Interestingly, the gout attack can spontaneously resolve within a few days.
However, the self-limited mechanism of gout remains elusive.
It has been demonstrated that CD14 plays an important role in self-remission of gout.
In this study, we found that the proportion of CD14-positive PBMCs was decreased in gout patients when compared with healthy controls and the serum sCD14 level was also considerably decreased in gout patients in comparison to healthy controls.
In addition, sCD14 levels were positively correlated with CRP levels.
Furthermore, the effect of MSU on the levels of CD14 in healthy volunteer’s PBMC was explored in in vitro experiment.
The results showed that CD14 expression on macrophage and sCD14 levels in the culture supernatants were significantly decreased after MSU treatment.
However, there was no significance in the levels of membrane CD14 and sCD14 in healthy volunteer’s PBMC stimulated by LPS.
Taken together, these results suggest that CD14 might play an important role in self-remission of gout.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Duan, Lihua& Luo, Jiao& Fu, Qiang& Shang, Ke& Wei, Yingying& Wang, Youlian…[et al.]. 2019. Decreased Expression of CD14 in MSU-Mediated Inflammation May Be Associated with Spontaneous Remission of Acute Gout. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1176684
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Duan, Lihua…[et al.]. Decreased Expression of CD14 in MSU-Mediated Inflammation May Be Associated with Spontaneous Remission of Acute Gout. Journal of Immunology Research No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1176684
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Duan, Lihua& Luo, Jiao& Fu, Qiang& Shang, Ke& Wei, Yingying& Wang, Youlian…[et al.]. Decreased Expression of CD14 in MSU-Mediated Inflammation May Be Associated with Spontaneous Remission of Acute Gout. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1176684
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176684
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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