Matrix Metalloproteinase-1 Gene Polymorphism Associated with Ultrasound-Assessed Carotid Thickness among Older Adults
المؤلفون المشاركون
Brito, Ciro José
Nóbrega, Otávio Toledo
Franco Moraes, Clayton
Tonet-Furioso, Audrey Cecília
Morais Junior, Gilberto Santos
Henriques, Adriane Dallanora
Rodrigues, Nathalia Oliveira
Gomes, Lucy Oliveira
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-21
دولة النشر
مصر
عدد الصفحات
6
الملخص EN
Background and Aim.
Due to the high incidence of vascular diseases, it is necessary to identify new circulating or structural markers for predicting risk for chronic diseases.
Some studies suggest that MMP1 gene polymorphisms are associated with the enzyme expression levels in situ (e.g., in atherosclerotic plaques).
Objectives.
Thus, the study of this polymorphism may help understanding the pathophysiology of coronary disease.
Methods.
We performed cross-sectional clinical and laboratory evaluations (including measurement of intima-media thickness of carotid arteries) and genotyping of the MMP1 SNP rs495366 (A/G) in 366 elderly people.
Results.
No significant differences between genotypes were noted for biochemical, metabolic, inflammatory, or clinical variables except for a significant difference in intima-media thickness for the left carotid artery and a trend toward significance for the right counterpart.
Conclusion.
Carriers of the allele associated with lower MMP1 expression (allele A) presented greater carotid thickness.
We suggest that the phenomenon can be explained by impaired remodeling of the arterial wall (poor degradation of collagen fibers in this scenario), yielding carotid wall thickening and a greater intrinsic risk for cerebrovascular events.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morais Junior, Gilberto Santos& Rodrigues, Nathalia Oliveira& Henriques, Adriane Dallanora& Tonet-Furioso, Audrey Cecília& Brito, Ciro José& Gomes, Lucy Oliveira…[et al.]. 2018. Matrix Metalloproteinase-1 Gene Polymorphism Associated with Ultrasound-Assessed Carotid Thickness among Older Adults. Journal of Aging Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1180728
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morais Junior, Gilberto Santos…[et al.]. Matrix Metalloproteinase-1 Gene Polymorphism Associated with Ultrasound-Assessed Carotid Thickness among Older Adults. Journal of Aging Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1180728
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morais Junior, Gilberto Santos& Rodrigues, Nathalia Oliveira& Henriques, Adriane Dallanora& Tonet-Furioso, Audrey Cecília& Brito, Ciro José& Gomes, Lucy Oliveira…[et al.]. Matrix Metalloproteinase-1 Gene Polymorphism Associated with Ultrasound-Assessed Carotid Thickness among Older Adults. Journal of Aging Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1180728
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1180728
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر