Cell Counts, rather than Proportion, of CD8PD-1 Tumor-Infiltrating Lymphocytes in a Tumor Microenvironment Associated with Pathological Characteristics of Chinese Invasive Ductal Breast Cancer
المؤلفون المشاركون
Song, Qingkun
Shi, Feng
Adair, Maya
Chang, Hong
Guan, Xiudong
Zhao, Yanjie
Li, Yuchen
Wu, Guangjiang
Wu, Jiangping
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
This study is aimed at investigating the association of exhausted CD8+ tumor-infiltrating lymphocytes with clinic-pathological factors.
Methods.
133 patients diagnosed with primary invasive ductal breast cancer were recruited into the cross-sectional study consecutively.
Immunohistochemistry was used to detect biomarker expression on formalin-fixed and paraffin-embedded sections.
Double staining of CD8 and PD-1 was conducted on lymphocytes.
Results.
The proportion of CD8+/PD-1- TILs was 16% among patients with axillary lymph node metastasis, significantly lower than those without metastasis (24%).
The expression of CK7, CK20, or Ki-67 was not related with the proportion of phenotypes of CD8/PD-1 TILs.
Younger patients had more cell counts of CD8+/PD-1- TILs than elderly patients (18/HPF vs.
9/HPF, p<0.05).
Patients with axillary lymph node metastasis had less CD8+/PD-1- TILs than those without metastasis (11/HPF vs.
27/HPF, p<0.05).
Median counts of CD8+/PD-1- TILs among patients with CK20 and E-Cad expression were 33/HPF and 14/HPF, significantly higher than those among patients with negative CK20 (16/HPF) and E-Cad expression (6/HPF).
Ki-67 index had a significant correlation with cell counts of CD8+/PD-1+ TILs and CD8+/PD-1- TILs, and the correlation coefficients were 0.19 and 0.21 (p<0.05), respectively.
Conclusion.
The proportion of CD8+/PD-1- TILs was related with metastatic status of the axillary lymph node but cell counts of CD8+/PD-1- TILs were related with metastatic status of the axillary lymph node and expression of CK7, CK20, E-Cad, and Ki-67.
Absolute cell counts, not proportion of CD8/PD-1 TILs, were more likely to distinguish clinic and pathologic characteristics of breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Qingkun& Shi, Feng& Adair, Maya& Chang, Hong& Guan, Xiudong& Zhao, Yanjie…[et al.]. 2019. Cell Counts, rather than Proportion, of CD8PD-1 Tumor-Infiltrating Lymphocytes in a Tumor Microenvironment Associated with Pathological Characteristics of Chinese Invasive Ductal Breast Cancer. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1180962
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Qingkun…[et al.]. Cell Counts, rather than Proportion, of CD8PD-1 Tumor-Infiltrating Lymphocytes in a Tumor Microenvironment Associated with Pathological Characteristics of Chinese Invasive Ductal Breast Cancer. Journal of Immunology Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1180962
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Qingkun& Shi, Feng& Adair, Maya& Chang, Hong& Guan, Xiudong& Zhao, Yanjie…[et al.]. Cell Counts, rather than Proportion, of CD8PD-1 Tumor-Infiltrating Lymphocytes in a Tumor Microenvironment Associated with Pathological Characteristics of Chinese Invasive Ductal Breast Cancer. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1180962
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1180962
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر