Treatment with Apocynin Limits the Development of Acute Graft-versus-Host Disease in Mice
المؤلفون المشاركون
Athayde, Rayssa Maciel
Pinho, Vanessa
Rezende, Barbara Maximino
Bernardes, Priscila T. T.
Gonçalves, William Antonio
de Resende, Carolina Braga
Ávila, Thiago Vinicius
Martins, Débora Gonzaga
Castor, Marina G. M.
Teixeira, Mauro Martins
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Graft-versus-host disease (GVHD) is the most serious complication limiting the clinical utility of allogeneic hematopoietic stem cell transplantation (HSCT), in which lymphocytes of donors (graft) are activated in response to the host antigen.
This disease is associated with increased inflammatory response through the release of inflammatory mediators such as cytokines, chemokines, and reactive oxygen species (ROS).
In this study, we have evaluated the role of ROS in GVHD pathogenesis by treatment of recipient mice with apocynin (apo), an inhibitor of intracellular translocation of cytosolic components of NADPH oxidase complex.
The pharmacological blockade of NADPH oxidase resulted in prolonged survival and reduced GVHD clinical score.
This reduction in GVHD was associated with reduced levels of ROS and TBARS in target organs of GVHD in apocynin-treated mice at the onset of the mortality phase.
These results correlated with reduced intestinal and liver injuries and decreased levels of proinflammatory cytokines and chemokines.
Mechanistically, pharmacological blockade of the NADPH oxidase was associated with inhibition of recruitment and accumulation of leukocytes in the target organs.
Additionally, the chimerism remained unaffected after treatment with apocynin.
Our study demonstrates that ROS plays an important role in mediating GVHD, suggesting that strategies aimed at blocking ROS production may be useful as an adjuvant therapy in patients subjected to bone marrow transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rezende, Barbara Maximino& Bernardes, Priscila T. T.& Gonçalves, William Antonio& de Resende, Carolina Braga& Athayde, Rayssa Maciel& Ávila, Thiago Vinicius…[et al.]. 2019. Treatment with Apocynin Limits the Development of Acute Graft-versus-Host Disease in Mice. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1181024
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rezende, Barbara Maximino…[et al.]. Treatment with Apocynin Limits the Development of Acute Graft-versus-Host Disease in Mice. Journal of Immunology Research No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1181024
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rezende, Barbara Maximino& Bernardes, Priscila T. T.& Gonçalves, William Antonio& de Resende, Carolina Braga& Athayde, Rayssa Maciel& Ávila, Thiago Vinicius…[et al.]. Treatment with Apocynin Limits the Development of Acute Graft-versus-Host Disease in Mice. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1181024
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181024
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر