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Skin-Resident γδ T Cells Exhibit Site-Specific Morphology and Activation States
المؤلفون المشاركون
Gilron, Ian
Marshall, Abigail S.
Silva, Jaqueline Raymondi
Bannerman, Courtney A.
Ghasemlou, Nader
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Skin-resident γδ T cells play an important role in maintaining the immune barrier at the epithelial surface.
Their roles in wound healing, regulation of immune response to injury, and reepithelialization have been characterized extensively in the mouse, though their function in human skin remains largely unknown.
Human skin-resident γδ T cells sparsely populate the skin and are often small and rounded in appearance.
Those in the mouse ear and back, which line the dermal barrier, are highly arborized cells with many processes extending from the cell body.
To date, these cells have been studied primarily in the mouse ear and back; however, it is important to further identify and characterize γδ T cells in other body sites to better understand their function and study their contribution to injury and disease.
We developed a novel method to visualize these cells in the skin (whole-mount and cryosections) that when combined with flow cytometry allowed us to assess differences in skin-resident γδ T cell numbers, morphology, and activation state in the ear, back, and footpad (chosen for their importance in immunological and pain research).
In comparing cell length, number of dendritic processes, and expression of the activation marker CD69, we found that γδ T cell morphology and activation states vary significantly among the three tissue environments.
Specifically, γδ T cells in the footpad are smaller, have fewer processes, and show the highest levels of activation compared to back- and ear-resident cells.
Our observations suggest that our understanding of skin-resident γδ T cell functionality, drawn from the experiments performed in the ear and back tissue, may not be applicable to all skin environments.
The footpad-resident cells also more closely resemble γδ T cells in human skin, suggesting that cells in this tissue environment may serve as a better translational model when studying γδ T cell function/activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marshall, Abigail S.& Silva, Jaqueline Raymondi& Bannerman, Courtney A.& Gilron, Ian& Ghasemlou, Nader. 2019. Skin-Resident γδ T Cells Exhibit Site-Specific Morphology and Activation States. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1181028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marshall, Abigail S.…[et al.]. Skin-Resident γδ T Cells Exhibit Site-Specific Morphology and Activation States. Journal of Immunology Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1181028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marshall, Abigail S.& Silva, Jaqueline Raymondi& Bannerman, Courtney A.& Gilron, Ian& Ghasemlou, Nader. Skin-Resident γδ T Cells Exhibit Site-Specific Morphology and Activation States. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1181028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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