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Anti-inflammatory Property of Galectin-1 in a Murine Model of Allergic Airway Inflammation
المؤلفون المشاركون
Liu, Rongyu
Wang, Muzi
Lv, Yunxiang
Dai, Mengyuan
Chen, Fangfang
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Galectin-1 (Gal-1) has immunomodulatory activities in various allergic inflammatory disorders, but its potential anti-inflammatory properties on allergic airway diseases have not been confirmed.
We explored the pharmacological effects of Gal-1 on the progression of allergic airway inflammation and investigated the underlying mechanism.
Female C57BL/6 mice were sensitized on day 0 and challenged with ovalbumin (OVA) on days 14-17 to establish an allergic airway inflammation model.
In the challenge phase, a subset of mice was treated intraperitoneally with recombinant Gal-1 (rGal-1) or dexamethasone (Dex).
We found that rGal-1 inhibited pulmonary inflammatory cell recruitment, mucus secretion, bronchoalveolar lavage fluid (BALF) inflammatory cell infiltration, and cytokine production.
The treatment also suppressed the infiltration of eosinophils into the allergic lung as indicated by decreased expression levels of eotaxin and eosinophil peroxidase (EPX).
However, only the expression levels of IL-25, neither IL-33 nor TSLP, were significantly decreased in the lung by rGal-1 treatment.
These immunomodulatory effects in the allergic lung were correlated with the activation of extracellular signal-regulated kinase (ERK) signaling pathway and downregulation of endogenous Gal-1.
In addition, rGal-1 reduced the plasma concentrations of anti-OVA immunoglobulin E (IgE) and IL-17.
Our findings suggest that rGal-1 is an effective therapy for allergic airway inflammation in a murine model and may be a potential pharmacological target for allergic airway inflammatory diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lv, Yunxiang& Dai, Mengyuan& Wang, Muzi& Chen, Fangfang& Liu, Rongyu. 2019. Anti-inflammatory Property of Galectin-1 in a Murine Model of Allergic Airway Inflammation. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1181148
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lv, Yunxiang…[et al.]. Anti-inflammatory Property of Galectin-1 in a Murine Model of Allergic Airway Inflammation. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1181148
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lv, Yunxiang& Dai, Mengyuan& Wang, Muzi& Chen, Fangfang& Liu, Rongyu. Anti-inflammatory Property of Galectin-1 in a Murine Model of Allergic Airway Inflammation. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1181148
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181148
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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