Damage-Associated Molecular Patterns and Myeloid-Derived Suppressor Cells in Bronchoalveolar Lavage Fluid in Chronic Obstructive Pulmonary Disease Patients
المؤلفون المشاركون
Brajer-Luftmann, Beata
Nowicka, Agata
Kaczmarek, Mariusz
Wyrzykiewicz, Magdalena
Yasar, Senan
Piorunek, Tomasz
Sikora, Jan
Batura-Gabryel, Halina
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Myeloid-derived suppressor cells (MDSCs) are present in the human lung microenvironment, and they may be involved in the local inflammatory process in chronic obstructive pulmonary disease (COPD).
Chronic inflammation in COPD may induce immunogenic cell death of structural airway cells, causing the release of damage-associated molecular patterns (DAMPs).
DAMPs may activate the innate and adaptive immune system.
The relationship between MDSCs and DAMPs in COPD is poorly described in the available literature.
Objectives.
(1) Assessment of MDSC percentage and DAMP concentration in bronchoalveolar lavage fluid (BALF) and peripheral blood.
(2) Analysis of the relationship between MDSC percentage and chosen DAMPs.
Patients and Methods.
30 COPD patients were included.
Using monoclonal antibodies directly conjugated with fluorochromes in flow cytometry, MDSCs were assessed in BALF and peripheral blood.
The concentration of DAMPs was estimated using sandwich ELISA.
Using the Bradford method, the total protein concentrations were evaluated.
Results.
The percentage of MDSCs among MC in BALF correlated well with the concentration of defensin and heat shock protein 27.
Assessing the percentage of MDSCs among all leukocytes in BALF, we revealed a significant correlation with the concentration of defensin, hyaluronic acid, and surfactant protein A.
No dependencies occurred between DAMPs and MDSCs in peripheral blood.
Conclusion.
MDSCs and DAMPs occur in the COPD patient lung microenvironment.
Significant correlations between them found in BALF may indicate their influence on the local inflammatory process in COPD.
These relationships allow better understanding of the inflammatory process in COPD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brajer-Luftmann, Beata& Nowicka, Agata& Kaczmarek, Mariusz& Wyrzykiewicz, Magdalena& Yasar, Senan& Piorunek, Tomasz…[et al.]. 2019. Damage-Associated Molecular Patterns and Myeloid-Derived Suppressor Cells in Bronchoalveolar Lavage Fluid in Chronic Obstructive Pulmonary Disease Patients. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1181155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brajer-Luftmann, Beata…[et al.]. Damage-Associated Molecular Patterns and Myeloid-Derived Suppressor Cells in Bronchoalveolar Lavage Fluid in Chronic Obstructive Pulmonary Disease Patients. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1181155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brajer-Luftmann, Beata& Nowicka, Agata& Kaczmarek, Mariusz& Wyrzykiewicz, Magdalena& Yasar, Senan& Piorunek, Tomasz…[et al.]. Damage-Associated Molecular Patterns and Myeloid-Derived Suppressor Cells in Bronchoalveolar Lavage Fluid in Chronic Obstructive Pulmonary Disease Patients. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1181155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر