Percutaneous Mitral Valve Repair versus Optimal Medical Therapy in Patients with Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis

المؤلفون المشاركون

Alkhouli, Mohamad
Khan, Muhammad Shahzeb
Lodhi, Muhammad Uzair
Usman, Muhammad Shariq
Siddiqi, Tariq Jamal
Khan, Muhammad Arbaz Arshad
Khan, Safi U.
Syed, Intekhab Askari
Rahim, Mustafa
Naidu, Srihari S.
Doukky, Rami

المصدر

Journal of Interventional Cardiology

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-04-21

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض

الملخص EN

Objectives.

To compare percutaneous mitral valve repair (PMVR) with optimal medical therapy (OMT) in patients with heart failure (HF) and severe functional mitral regurgitation (FMR).

Background.

Many patients with HF and FMR are not suitable for surgical valve replacement and remain symptomatic despite maximal OMT.

PMVR has recently emerged as an alternative solution.

Methods.

We performed a systematic review and a meta-analysis to address this question.

Cochrane CENTRAL, MEDLINE, and Scopus were searched for randomized (RCT) and nonrandomized studies comparing PMVR with OMT in patients with HF and FMR.

Primary endpoint was all-cause midterm mortality (at 1 and 2 years).

Secondary endpoints were 30-day mortality and cardiovascular mortality and HF hospitalizations, at maximum follow-up.

Studies including mixed cohort of degenerative and functional MR were allowed initially but were excluded in a secondary sensitivity analysis for each of the study’s end points.

This meta-analysis was performed following the publication of two RCTs (MITRA-FR and COAPT).

Results.

Eight studies (six observational, two RCTs) comprising 3,009 patients were included in the meta-analysis.

In comparison with OMT, PMVR significantly reduced 1-year mortality (RR: 0.70 [0.56, 0.87]; p=0.002; I2=47.6%), 2-year mortality (RR: 0.63 [0.55, 0.73]; p<0.001; I2=0%), and cardiovascular mortality (RR: 0.32 [0.23, 0.44]; p<0.001; I2=0%).

No significant difference between PMVR+OMT and OMT was noted in HF hospitalization (HR: 0.69 [0.40, 1.20]; p=0.19; I2=85%) and 30-day mortality (RR: 1.13 [0.68, 1.87]; p=0.16; I2=0%).

Conclusions.

In comparison with OMT, PMVR significantly reduces 1-year mortality, 2-year mortality, and cardiovascular mortality in patients with HF and severe MR.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lodhi, Muhammad Uzair& Usman, Muhammad Shariq& Siddiqi, Tariq Jamal& Khan, Muhammad Shahzeb& Khan, Muhammad Arbaz Arshad& Khan, Safi U.…[et al.]. 2019. Percutaneous Mitral Valve Repair versus Optimal Medical Therapy in Patients with Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis. Journal of Interventional Cardiology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1181206

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lodhi, Muhammad Uzair…[et al.]. Percutaneous Mitral Valve Repair versus Optimal Medical Therapy in Patients with Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis. Journal of Interventional Cardiology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1181206

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lodhi, Muhammad Uzair& Usman, Muhammad Shariq& Siddiqi, Tariq Jamal& Khan, Muhammad Shahzeb& Khan, Muhammad Arbaz Arshad& Khan, Safi U.…[et al.]. Percutaneous Mitral Valve Repair versus Optimal Medical Therapy in Patients with Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis. Journal of Interventional Cardiology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1181206

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1181206