Synthesis of Mixed Ligand Ruthenium (IIIII) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms
المؤلفون المشاركون
Odisitse, Sebusi
Matshwele, James T. P.
Nareetsile, Florence
Mapolelo, Daphne
Matshameko, Pearl
Leteane, Melvin
Nkwe, David O.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The potential antimicrobial properties of a tridentate polypyridyl ligand 4-butoxy-N,N-bis(pyridin-2-ylmethyl)aniline (BUT) 1 and its corresponding mixed ligand ruthenium complexes were investigated on drug-resistant and non-drug-resistant bacterial species.
The ligand and its complexes were synthesized and successfully characterized by 1H NMR, UV/Vis, and FTIR spectra; ESI-MS; and magnetic susceptibility.
Electronic spectra and magnetic susceptibility of these Ru(II)/(III) complexes suggest that they are of a low spin crystal field split, where the Ru(III) is a d5 and Ru(II) d6 low spin.
These compounds were tested for antibacterial activity on two bacterial species: Staphylococcus aureus (S.
aureus) and Klebsiella pneumoniae (K.
pneumoniae), as well as their drug-resistant strains methicillin-resistant Staphylococcus aureus (MRSA) and multidrug resistant Klebsiella pneumoniae (MDR K.
pneumoniae).
All the compounds inhibited growth of the two non-drug-resistant bacteria and only one drug-resistant strain MRSA.
However, only the ligands BUT and 2,2-dipyridylamine showed activity against MRSA, while all complexes did not show any antibacterial activity on MRSA.
We observed large zones of inhibition for the Gram-positive S.
aureus and MRSA bacteria, compared to the Gram-negative K.
pneumoniae bacteria.
DNA cleavage studies with gel electrophoresis showed denatured bacterial DNA on the gel from all the complexes, with the exception of the ligand, suggesting DNA nuclease activity of the complexes in the bacterial DNA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matshwele, James T. P.& Nareetsile, Florence& Mapolelo, Daphne& Matshameko, Pearl& Leteane, Melvin& Nkwe, David O.…[et al.]. 2020. Synthesis of Mixed Ligand Ruthenium (IIIII) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1181480
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matshwele, James T. P.…[et al.]. Synthesis of Mixed Ligand Ruthenium (IIIII) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms. Journal of Chemistry No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1181480
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matshwele, James T. P.& Nareetsile, Florence& Mapolelo, Daphne& Matshameko, Pearl& Leteane, Melvin& Nkwe, David O.…[et al.]. Synthesis of Mixed Ligand Ruthenium (IIIII) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1181480
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181480
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر