Efficacy of Tumor-Infiltrating Lymphocytes Combined with IFN-α in Chinese Resected Stage III Malignant Melanoma
المؤلفون المشاركون
Gao, Quan-Li
Li, Wei
Xu, Linping
Wang, Yaomei
Zhao, Lingdi
Kellner, Daniel B.
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
This study aims to explore the efficacy of tumor-infiltrating lymphocytes (TIL) along with interferon-α (IFN-α) to treat stage III malignant melanoma (MM) patients in China.
Methods.
Between May 2010 and October 2014, 77 patients of stage III MM who underwent surgery were collected in this study.
These patients were divided into two groups: patients who received TIL + IFN-α ± RetroNectin-activated cytokine-induced killer cells (R-CIK) in Arm 1 (n=27) and IFN-α ± R-CIK in Arm 2 (n=50) as adjuvant therapy.
The primary endpoints were disease-free survival (DFS) time and DFS rates measured at time points of 1, 2, and 3 years.
The secondary endpoints were overall survival (OS) rates measured at time points of 1, 2, 3, and 5 years as well as OS as evaluated by Kaplan-Meier.
Results.
Our results indicated that the median DFS and OS in Arm 1 were significantly better than those in Arm 2.
The data also demonstrated that DFS rate and OS rates in Arm 1 were significantly better than those in Arm 2 at all measured time points.
Conclusion.
Patients who undergo surgical excision of stage III MM appear to enjoy prolonged DFS and OS when treated with TIL + IFN-α compared to IFN-α alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Wei& Xu, Linping& Wang, Yaomei& Zhao, Lingdi& Kellner, Daniel B.& Gao, Quan-Li. 2017. Efficacy of Tumor-Infiltrating Lymphocytes Combined with IFN-α in Chinese Resected Stage III Malignant Melanoma. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181553
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Wei…[et al.]. Efficacy of Tumor-Infiltrating Lymphocytes Combined with IFN-α in Chinese Resected Stage III Malignant Melanoma. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1181553
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Wei& Xu, Linping& Wang, Yaomei& Zhao, Lingdi& Kellner, Daniel B.& Gao, Quan-Li. Efficacy of Tumor-Infiltrating Lymphocytes Combined with IFN-α in Chinese Resected Stage III Malignant Melanoma. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181553
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181553
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر