Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection

المؤلفون المشاركون

Kimuda, Simon G.
Nalwoga, Angela
Levin, Jonathan
Elliott, Alison M.
Cose, Stephen
Andia-Biraro, Irene
Ottenhoff, Tom H. M.
Franken, Kees L. M. C.

المصدر

Journal of Immunology Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-02-01

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأحياء

الملخص EN

Latent tuberculosis infection (LTBI) is evidence of immunological control of tuberculosis.

Dormancy survival regulator (DosR) regulon-encoded proteins may have a role in the maintenance of LTBI.

T cell responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were found to be most frequent among household contacts of TB cases from Uganda compared to other DosR proteins, but antibody responses were not described.

We characterized antibody responses to these proteins in individuals from Uganda.

Antibodies to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were measured in 68 uninfected individuals, 62 with LTBI, and 107 with active pulmonary tuberculosis (APTB) cases.

There were no differences in the concentrations of antibodies to Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins between individuals with LTBI and APTB and those who were uninfected.

LTBI was associated with higher concentrations of antibodies to Rv1733c in female participants [adjusted geometric mean ratio: 1.812, 95% confidence interval (CI): 1.105 2.973, and p=0.019] but not in males (p value for interaction = 0.060).

Antibodies to the four DosR regulon-encoded proteins investigated may not serve as good biomarkers of LTBI in the general population.

More of the M.tb proteome needs to be screened to identify proteins that induce strong antibody responses in LTBI.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kimuda, Simon G.& Nalwoga, Angela& Levin, Jonathan& Franken, Kees L. M. C.& Ottenhoff, Tom H. M.& Elliott, Alison M.…[et al.]. 2017. Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181580

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kimuda, Simon G.…[et al.]. Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1181580

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kimuda, Simon G.& Nalwoga, Angela& Levin, Jonathan& Franken, Kees L. M. C.& Ottenhoff, Tom H. M.& Elliott, Alison M.…[et al.]. Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181580

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1181580