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Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study
المؤلفون المشاركون
Milkiewicz, Malgorzata
Norman, Gary L.
Wasik, Urszula
Bogdanos, Dimitrios P.
Wunsch, Ewa
Rigopoulou, Eirini I.
Milkiewicz, Piotr
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Recent GWAS in primary biliary cholangitis (PBC) showed strong associations with SNPs located within interleukin-12 receptor (IL12R) beta-2 (IL12RB2) gene.
Aims.
We assessed whether genetic variation of IL12RB2 is associated with laboratory and clinical features of PBC.
Methods.
Genomic DNA was isolated from 306 patients with PBC and 258 age/gender-matched controls.
PBC-specific anti-mitochondrial antibodies (AMA) were tested in all subjects by ELISA.
Two SNPs, rs3790567 and rs6679356, of IL12RB2 were genotyped using the MGB-TaqMan SNP assay.
Results.
Despite comparable age at diagnosis of cirrhotic and noncirrhotic PBC patients, allele A of rs3790567 and allele C of rs6679356 were overrepresented in the former rather than the latter group ( p = 0.0009 and p = 0.002 , resp.).
The risk of cirrhosis at presentation increased when allele A and allele C coexisted.
AMA-M2 titres were significantly higher in AA homozygotes of rs3790567 compared to GG homozygotes ( 132 ± 54 versus 103 ± 62 , p = 0.02 ) and in rs6679356 when C allele was present ( p = 0.038 ).
There were no other significant associations between IL12RB2 polymorphisms and laboratory or clinical features.
Conclusion.
In this first study analyzing phenotypic features of PBC carriers of the IL12RB2 polymorphisms, we found that carriers are more frequently cirrhotic at diagnosis and have significantly higher titres of AMA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wasik, Urszula& Wunsch, Ewa& Norman, Gary L.& Rigopoulou, Eirini I.& Bogdanos, Dimitrios P.& Milkiewicz, Piotr…[et al.]. 2017. Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1181604
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wasik, Urszula…[et al.]. Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study. Journal of Immunology Research No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1181604
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wasik, Urszula& Wunsch, Ewa& Norman, Gary L.& Rigopoulou, Eirini I.& Bogdanos, Dimitrios P.& Milkiewicz, Piotr…[et al.]. Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1181604
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181604
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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