Hydroxychloroquine Use in Lupus Patients during Pregnancy Is Associated with Longer Pregnancy Duration in Preterm Births
المؤلفون المشاركون
Kroese, S. J.
de Hair, M. J. H.
Limper, M.
Lely, A. T.
van Laar, J. M.
Derksen, R. H. W. M.
Fritsch-Stork, R. D. E.
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effect of hydroxychloroquine (HCQ) in pregnant women with systemic lupus erythematosus (SLE).
Methods.
In SLE pregnancies of a single Dutch center (2000–2015), lupus activity and flares before and during pregnancy and postpartum were assessed using the SLE Disease Activity Index (SLEDAI)/SLEPDAI (SLEDAI adjusted for pregnancy).
The association between HCQ use and pregnancy outcomes (early spontaneous abortion, fetal death, and preterm and term live birth) was analyzed using generalized estimating equations (GEE) accounting for the occurrence of multiple pregnancies per patient.
Analyses were adjusted for antiphospholipid antibody (aPL) status.
Results.
110 pregnancies (63 mostly Caucasian patients) were included, of which, in 30, HCQ was used; overall occurrence of flares was low (non-HCQ group: 5 mild (6.4%) and 2 severe (2.6%); HCQ group: 2 mild (6.7%) and no severe flares).
The HCQ group showed a trend towards lower dosage of prednisone (OR 0.2 (95% CI 0.0–1.4); p=0.10).
Pregnancy outcomes were comparable between groups.
Among preterm live births, pregnancy duration was significantly longer in HCQ users (2.4 weeks (95% CI 1.0–3.8; p≤0.001)).
Conclusion.
HCQ use was associated with longer pregnancy duration in the vulnerable preterm birth population, underscoring the beneficial effect of HCQ use during pregnancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kroese, S. J.& de Hair, M. J. H.& Limper, M.& Lely, A. T.& van Laar, J. M.& Derksen, R. H. W. M.…[et al.]. 2017. Hydroxychloroquine Use in Lupus Patients during Pregnancy Is Associated with Longer Pregnancy Duration in Preterm Births. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1181649
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kroese, S. J.…[et al.]. Hydroxychloroquine Use in Lupus Patients during Pregnancy Is Associated with Longer Pregnancy Duration in Preterm Births. Journal of Immunology Research No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1181649
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kroese, S. J.& de Hair, M. J. H.& Limper, M.& Lely, A. T.& van Laar, J. M.& Derksen, R. H. W. M.…[et al.]. Hydroxychloroquine Use in Lupus Patients during Pregnancy Is Associated with Longer Pregnancy Duration in Preterm Births. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1181649
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181649
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر