In Vitro Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis
المؤلفون المشاركون
Santos, Diógenes Santiago
Carvalho, Edgar M.
Carvalho, Natália B.
Amorim, Camila F.
Oliveira Prates, Fernanda Ventin de
Silva, Rafael de Castro da
Dourado, Mayra Elizabeth Ferreira
Machado, Paulo Roberto Lima
Pacheco, Fernanda Grendene
Corte, Temis Weber Furlanetto
Machado, Pablo
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-27
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Cutaneous leishmaniasis (CL) is the most common clinical form of American tegumentary leishmaniasis caused by Leishmania (Viannia) braziliensis.
CL is associated with a strong Th1 immune response.
This exacerbated inflammatory response is correlated with severity of disease and delays the healing time of the ulcer.
The fourth-generation immucillin derivative (DI4G), a potent inhibitor of purine nucleoside phosphorylase, has been proposed as a promising agent in the treatment of diseases associated with T cell activation.
Herein, we evaluated the in vitro immunomodulatory activity of DI4G in cells of patients presenting with CL.
Peripheral blood mononuclear cells (PBMC) from CL patients were stimulated with soluble leishmania antigen (SLA), in the presence or absence of DI4G, and IFN-γ, TNF, CXCL9, and CXCL10 levels were determined by ELISA.
Lymphocyte proliferation in the presence or absence of DI4G was also evaluated, using flow cytometry.
DI4G was able to decrease (p<0.05) IFN-γ production but did not change the TNF, CXCL9, and CXCL10 levels.
DI4G decreased (p<0.05) the lymphoproliferative response mediated by CD8+ T cells, but not that by CD4+ T cells.
DI4G is able to attenuate the exaggerated immune response in CL, exhibiting immunomodulatory activity in IFN-γ production and in CD8+ T cell proliferation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carvalho, Natália B.& Oliveira Prates, Fernanda Ventin de& Silva, Rafael de Castro da& Dourado, Mayra Elizabeth Ferreira& Amorim, Camila F.& Machado, Paulo Roberto Lima…[et al.]. 2017. In Vitro Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1181664
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carvalho, Natália B.…[et al.]. In Vitro Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis. Journal of Immunology Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1181664
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carvalho, Natália B.& Oliveira Prates, Fernanda Ventin de& Silva, Rafael de Castro da& Dourado, Mayra Elizabeth Ferreira& Amorim, Camila F.& Machado, Paulo Roberto Lima…[et al.]. In Vitro Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1181664
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181664
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر